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China Enters Bird Flu Vaccine Race

'Whole-Virus' Approach Spares Hard-to-Get Ingredients
WebMD Health News
Reviewed by Louise Chang, MD

Sept. 6, 2006 -- Chinese researchers report that a new bird flu vaccine shows promise in early human tests.

Like the previously announced Glaxo and Sanofi bird fluflu vaccines, the Chinese H5N1 bird flu vaccine is given with an immune-boosting substance called an adjuvant.

Jiangtao Lin, MD, of Beijing's Chinese-Japanese Friendship Hospital, and colleagues tested various doses of the vaccine in 120 adult volunteers aged 18-60.

They found that it worked best when given in two 10-microgram doses four weeks apart.

That's better than the Sanofi vaccine, which needs two 30-microgram doses. But it's not as low an effective dose as that reported for the Glaxo vaccine, which needs two 3.8-microgram doses.

Dose-Sparing Bird Flu Vaccines

Why is a low dose important? In an editorial accompanying the Lin report, British infectious disease specialist Iain Stephenson, MRCP, notes that if there's a bird-flu pandemic, the world will need hundreds of millions of doses -- fast.

This means scientists will be trying to make as much of the vaccine's main ingredient -- the vaccine antigen -- as quickly as possible. The lower the dose, the more doses you get. That's why researchers striving for a bird flu vaccine are looking for "dose-sparing" techniques.

Based on the seasonal flu vaccine, Stephenson estimates, current manufacturing processes could produce about 900 million 15-microgram doses of bird flu vaccine in six months. At two doses a person, this means 450 million people could be vaccinated within six months of a pandemic. A person would be protected only after the second dose, given one month after the first.

The Chinese vaccine, made by Sinovac Biotech Co. Ltd. in Beijing, uses a different approach than other experimental bird flu vaccines. Instead of using just the H5 protein -- in what's known as the "split virion" approach -- the Sinovac vaccine uses a whole killed virus. The vaccine virus is genetically engineered to lack the virulence gene that makes it lethal to the hen's eggs in which it is grown.

The Glaxo vaccine seems to offer more doses for less antigen: 3.8 micrograms versus 10 micrograms per dose. However, the Glaxo vaccine uses the split-virion approach. Lin and colleagues note that making a flu vaccine this way wastes 20% to 30% of the vaccine antigen.

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