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Cholesterol-Lowering Drugs Tied to Flu Survival

Study: People Taking Statins Are Less Likely to Die From Influenza
WebMD Health News
Reviewed by Laura J. Martin, MD

Dec. 14, 2011 -- Each year, thousands of Americans die from the flu. Now, a new study suggests that certain drugs that lower cholesterol may also reduce the flu’s severity and may prevent flu deaths.

But don’t trade a prescription for statin pills for a flu shot or other protections just yet. Researchers say their findings need to be confirmed in a larger clinical trial.

The study compared the fates of slightly more than 3,000 people hospitalized with flu. About one-third of them were taking statins before or during their hospitalization.

Of those in the study, 5% (151 people) died within a month of their diagnosis.

But people taking statins were about 41% less likely to die after getting the flu than people who were not taking statins.

That was true even after researchers took into account a host of factors that could have played a role in a person’s recovery. They looked at age, race, and whether or not a person had gotten a flu shot. They noted chronic health problems like lung, heart, or kidney disease. They also checked to see if people were promptly prescribed antiviral medications to fight the flu.

The study is published in The Journal of Infectious Disease.

Should Statins Be Tested Against the Flu?

The finding echoes two previous studies that also found that statins were associated with some protection from the worst flu outcomes, including pneumonia, hospitalization, and death.

Researchers say that’s enough evidence to test statins in a large clinical trial to see if they can help prevent flu deaths.

There are quite a few caveats to a study like this that relies on an observed association, says researcher Ann R. Thomas, MD, MPH, a public health doctor with the Oregon Public Health Division, in Portland. “But I think it’s good enough that someone will invest in a clinical trial.”

Not everyone agrees that would be worthwhile strategy.

“At the end of the day, I’m not convinced that statins are protective,” against the flu, says Jeffrey C. Kwong, MD, a scientist with the Institute for Clinical Evaluative Science in Toronto.

Kwong has also studied statin use in people who get the flu. He was not involved in the current research, though he says it is well done.

He says his own experience suggests that other factors were probably behind the drugs’ supposed benefits.

“The people who receive statins are just inherently different from people who don’t receive statins,” he says.

One example that’s often seen in studies of this kind is something called the health user effect. People who take preventive medications like statins may simply be more interested in taking care of their health than people who don’t take them. That could also mean they are in better overall health and are therefore less likely to die of the flu.

Researchers say they couldn’t find any evidence of the healthy user effect in this study.

Kwong says it would be impossible to account for every possible difference that could skew the results.

“The statistical methods we have are generally inadequate to remove the [outside influences] that are there,” he tells WebMD.

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