Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

More Pounds Lost With Epilepsy Drug Zonegran, New Satiety Drug Axokine

April 8, 2003 -- Two new weight-loss drugs may help obese people, clinical trials suggest.

The findings come in two separate reports. In the first study, obese people lost 13 pounds after 16 weeks of adding the epilepsy drug Zonegran to a low-calorie diet. In the second study, the optimal dose of the experimental drug Axokine helped obese people lose nine pounds in 12 weeks. Both studies appear in the April 9 issue of TheJournal of the American Medical Association.

Zonegran is already FDA approved. It's used to treat epilepsy. During clinical trials, epilepsy patients treated with the drug lost weight. That was bad for them -- but it might be a good weight-loss drug.

Duke University researchers led by Kishore M. Gadde, MD, put 60 obese volunteers on a low-calorie diet. Half also got Zonegran; the others got a look-alike placebo. After 16 weeks, those who got only the diet lost about two pounds. But those getting Zonegran lost an average of 13 pounds. Side effects -- mostly fatigue -- were mild. However, Zonegran is known to cause dizziness, impaired thinking, and sleepiness in epilepsy patients. It's also been linked -- rarely -- to kidney stones. Zonegran's manufacturer, Elan Biopharmaceuticals, provided the drug for the study.

More weight-loss news from a special obesity issue of The Journal of the American Medical Association.

Weight-Loss Programs Keep Pounds Off

Jury Still Out on Low-Carbohydrate Diets

Obese Children Suffer Like Cancer Kids

Watching TV Instead of Your Waistline?

"The results of this short-term study provide preliminary evidence that [Zonegran], in conjunction with diet, can be more effective than diet alone for obese patients seeking to lose weight," Gadde and colleagues write.

Axokine is a brand new drug with hopes of being a totally different kind of weight-loss drug. It's a man-made chemical that mimics a chemical the brain makes to protect itself from injury. It was designed as a possible treatment for Lou Gehrig's disease. But when researchers gave the experimental drug to patients, they lost weight.

Later experiments showed why. The drug affects a powerful brain system called the leptin pathway. Leptin is a chemical messenger that tells you when you've had enough to eat. Obese people have leptin resistance; they lose the ability to know when they're full. Axokine apparently bypasses this resistance and flips the fullness switch.

Healthy Recipe Finder

Browse our collection of healthy, delicious recipes, from WebMD and Eating Well magazine.

Top searches: Chicken, Chocolate, Salad, Desserts, Soup

Heart Rate Calculator

Ensure you're exercising hard enough to get a good workout, but not strain your heart.

While you are exercising, you should count between...