Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Natural Hormone Oxyntomodulin May Trick the Body Into Feeling Full

Aug. 26, 2005 -- Daily injections of a natural hormone found in the gut may help people lose weight by helping them feel full after eating less.

A new study showed that overweight and obese people who received injections of the hormone oxyntomodulin 30 minutes before each meal, three times a day lost an average of about 5 pounds over a four-week period -- even though they were told to maintain their regular diet and exercise levels.

The hormone oxyntomodulin is one of several hormones found in the gut thought to regulate appetite. In particular, oxyntomodulin is released after eating food and promotes a feeling of fullness.

Researchers say that by increasing levels of this hormone before meals, overweight and obese people may be able eat less while still feeling full.

If further studies confirm these results, which appear in the current issue of the journal Diabetes, researchers say use of oxyntomodulin may offer a new way to treat the growing worldwide epidemic of obesity.

Hormone Helps People Eat Less and Lose Weight

In the study, researchers compared the effects of daily injections of the hormone on weight in a group of 26 overweight or obese men and women. Fourteen of the participants injected the hormone under the skin in the abdomen area 30 minutes before each meal, three times a day for four weeks. The rest of the participants acted as a comparison group and followed the same procedure using a placebo injection (saline solution).

All of the participants were asked to maintain their normal diet and exercise levels during the study.

After four weeks, the results showed that the people who used the hormone lost an average of about 5 pounds compared with an average of about 1 pound lost in the comparison group.

In addition, people who used oxyntomodulin also experienced a reduction in fat-related hormones that suggests a loss of fat deposits within the body. Leptin levels decreased; it is a hormone that is made predominately in fat cells. The amount of leptin in the blood is proportional to the amount body fat. It is known as one of the "hunger hormones."

The treatment group ate an average of 170 calories less at their first meal after receiving the hormone injection. By the last meal of the study, hormone users ate 250 calories less than the comparison group and reported no loss of food palatability.

Researchers say the weight loss was maintained during the entire four-week study period, but the participants in the treatment group gained back the weight within two weeks after the hormone injections stopped.

WebMD Health News

Healthy Recipe Finder

Browse our collection of healthy, delicious recipes, from WebMD and Eating Well magazine.

Top searches: Chicken, Chocolate, Salad, Desserts, Soup

Heart Rate Calculator

Ensure you're exercising hard enough to get a good workout, but not strain your heart.

While you are exercising, you should count between...