Skip to content
My WebMD Sign In, Sign Up

Weight Loss & Diet Plans

Font Size

Brain Protein May Curb Obesity

Early Tests of Rats on High-Fat Diet Show Less Obesity With Shots of TLQP-21 Protein
WebMD Health News
Reviewed by Louise Chang, MD

Sept. 18, 2006 -- A protein called TLQP-21 may boost metabolism and limit obesity, at least in rats, a new study shows.

The study appears in Proceedings of the National Academy of Sciences.

The researchers included Alessandro Bartolomucci, PhD. He works in Rome at the Institute of Neuroscience of the Consiglio Nazionale delle Ricerche (National Research Council).

Bartolomucci and colleagues spotted the TLQP-21 protein in rats' brains. They isolated TLQP-21 for lab tests on male rats.

First, the rats ate normal chow for four days. Then they went on a high-fat diet laced with lard.

The rats also got a steady stream of a solution with or without TLQP-21 directly into their brains around the clock for two weeks.

The rats that received TLQP-21 gained less weight and burned more calories at rest on the high-fat diet, compared with those that didn't get TLQP-21.

Metabolism increases were measured by taking the rats' rectal temperature. The rats in the TLQP-21 group showed a rise in rectal temperature.

No people were studied. So it's not known yet if TLQP-21 behaves the same way in people, or what its long-term effects are, even in rats.

TLQP-21 might be part of the complex mix of chemicals involved in obesity.

While scientists sort out the details, people who are overweight and who want to lose weight should talk to their doctors for pointers on safe, effective weight lossweight loss.

Today on WebMD

feet on scale
Woman looking at reflection in mirror
Hot cup of coffee
butter curl on knife
eating out healthy
Smiling woman, red hair
6-Week Challenges
Want to know more?
Build a Fitter Family Challenge – Get your crew motivated to move.
Feed Your Family Better Challenge - Tips and tricks to healthy up your diet.
Sleep Better Challenge - Snooze clues for the whole family.
I have read and agreed to WebMD's Privacy Policy.
Enter cell phone number
- -
Entering your cell phone number and pressing submit indicates you agree to receive text messages from WebMD related to this challenge. WebMD is utilizing a 3rd party vendor, CellTrust, to provide the messages. You can opt out at any time.
Standard text rates apply
What Girls Need To Know About Eating Disorders
teen squeezing into jeans
fitfor Teens