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Skin Patch May Stop Montezuma’s Revenge

Novel Vaccine Cuts Risk of Travelers’ Diarrhea by 75%
WebMD Health News
Reviewed by Louise Chang, MD

Sept. 19, 2007 (Chicago) -- Researchers have developed a skin patch that prevents the curse of many trips abroad: travelers’ diarrhea.

In a study of more than 150 travelers to Mexico and Guatemala, the novel vaccine cut the risk of moderate to severe diarrhea by 75%. Those who did get sick had a shorter, milder course of illness, says researcher Herbert DuPont, MD, director of the Center for Infectious Diseases at the University of Texas School of Public Health in Houston.

The vaccine, which looks like a large bandage, goes on your arm or leg, he says.

“The idea of putting a Band-Aid on yourself and immunizing yourself when you travel is truly novel and exciting,” DuPont tells WebMD.

The research was presented at a meeting of the American Society for Microbiology.

17 Million Travelers Struck Each Year

Intestinal illness caused by contaminated food and drink is the most common malady afflicting international travelers, particularly in developing countries.

Seventeen million travelers are struck each year, typically suffering agonizing bouts of vomiting and diarrhea that last about three to five days, says Gregory Glenn, MD, chief scientific officer of Iomai Corp., which is developing the patch and funded the study.

The illness also raises the risk of developing irritable bowel syndrome, or IBS, a chronic disorder of the intestines that causes belly pain, cramping or bloating, and diarrhea or constipation by 10% to 30%, Glenn says.

“Travelers’ diarrhea is a bigger deal than we thought, causing this syndrome that can last for years, even decades,” DuPont says.

How It Works

He says that the patch contains a toxin that causes traveler’s diarrhea. Once it’s absorbed through the skin, the body makes antibodies against the toxin.

Then, if you eat food that contains the strain of E. coli bacterium that causes the diarrhea, the antibodies evoke an immune reaction that prevents the toxin from causing disease, DuPont explains.

The new study included 170 volunteers who put on two patches containing either the vaccine or a placebo, two to three weeks apart, with the second patch administered at least a week before travel.

The volunteers stayed in Mexico or Guatemala for at least five days, during which they kept detailed diaries and received checkups.

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