Ulcer Treatment: 4 Drugs Better Than 3?
Four-Medication Regimen Beats Out Standard Three-Drug Approach in Study
Ulcer Treatment Study Results continued...
When the analysis was computed to include everyone who began the study,
including the eight who discontinued the treatments, the four-drug, seven-day
plan eliminated bacteria in 91.1%, the four-drug 10-day plan eliminated it in
88.9%, and the three-drug, 10-day plan eradicated bacteria in 75.6%.
Side effects reported by all groups were mostly minor, such as headache,
All patients he studied had not received treatment before, so Basu can't yet
say whether the new plan might be worth a try for those who have failed
Costs are comparable, Basu says. "LAC is about $400 for 10 days, and LOAD is
about $400 for seven days. LOAD 10 is about $535."
''It's a completely new regimen," says William Chey, MD, professor of
medicine at the University of Michigan, Ann Arbor, who reviewed the study
findings for WebMD.
He views the results as promising. "This is exciting news about a potential
new therapy," he says. New treatment regimens have been few in recent years, he
says, as the percentage of people with H. pylori in the U.S. has dropped
What strengthens the study finding that the four-day approach is more
effective, he says, is that "the eradication rate he got with [the three-day
approach] is exactly what you would expect based on other studies from the
U.S." In his recent review of published studies, Chey found an eradication rate
of about 77% with three-drug treatment plans, close to the 80% found in the new
Physicians should consider the new four-drug regimen, he says, adding that
further studies are needed. "The results are encouraging, and the eradication
rates with standard therapy are not very good."