Cirrhosis is a potentially life-threatening condition that occurs when inflammation and scarring damage the liver. A physical examination and medical history will be done first to assess symptoms of liver disease, to see whether liver disease is severe enough to cause signs of cirrhosis, and to help determine possible causes of liver damage.

A combination of tests may be used to diagnosis cirrhosis when a physical examination and medical history suggest that the condition may be present. Blood tests may help check for inflammation of the liver, assess liver function, and diagnose the cause of cirrhosis. Other tests provide images of the liver to look for tumors and blocked bile ducts and can be used to evaluate liver size and blood flow through the liver.

Liver biopsy, in which a sample of liver tissue is removed and analyzed, also may be done. It is the only test that can confirm a diagnosis of cirrhosis.

Blood tests that assess liver function

Measuring the levels of certain chemicals produced by the liver can help evaluate remaining liver function. Blood tests may be used to measure:

• Albumin and total serum protein. Albumin is a type of protein. Liver disease can cause a decrease in protein levels in the blood.
• Partial thromboplastin time or prothrombin time/INR. These tests measure blood-clotting factors that are produced in the liver.
• Bilirubin. Bilirubin is produced when the liver breaks down hemoglobin, the oxygen-carrying substance in red blood cells. Cirrhosis may cause elevated bilirubin levels, which causes jaundice.

Blood tests for inflammation of the liver

Blood tests may be done periodically to look at levels of liver enzymes. These tests can help show whether there is ongoing liver inflammation, although some people with cirrhosis have normal liver enzymes. The blood tests include:

• Aspartate aminotransferase (AST). An increased AST level (also called SGOT) may indicate injury to the liver and the death of liver cells.
• Alanine aminotransferase (ALT). An increased ALT level (also called SGPT) also may indicate injury to the liver and the death of liver cells.
• Lactate dehydrogenase (LDH). An increased LDH level also may indicate injury to the liver and the death of liver cells.
• Alkaline phosphatase (ALP). An increased ALP level may indicate blockage of bile ducts.
• Gamma-glutamyl transpeptidase (GGT). An increased level of GGT may mean alcohol use or blocked bile ducts are causing inflammation. The level of GGT also may increase with the use of certain medications, such as dilantin and phenobarbital. However, GGT may increase without inflammation.

Blood tests that may diagnose a cause of cirrhosis

Tests that may be done to check for conditions that may cause cirrhosis include:

• Antinuclear antibodies (ANA). ANA testing and anti-smooth-muscle antibody (ASMA) testing may help detect the presence of autoimmune chronic hepatitis.
• Antimitochondrial antibody test (AMA), which may help detect primary biliary cirrhosis.
• Ferritin and iron tests, which may help diagnose iron overload, or hemochromatosis.
• Virus antibody testing for hepatitis B and hepatitis C or tests for hepatitis virus genetic material, which may help diagnose infection with certain hepatitis viruses.
• Blood alcohol level (BAL) tests. These tests may detect alcohol use, which can cause alcoholic cirrhosis.
• Serum ceruloplasmin testing, which may help diagnose Wilson's disease.
• Alpha₁-antitrypsin level. This may diagnose a condition in which people lack this protein (alpha₁-antitrypsin deficiency).

Tests that provide an image of the liver