If you are:
Not Recommended: CROSSES PLACENTA WITH LARGEST TRANSFER IN 3RD TRIM; ANIMAL DATA SUG DEV TOX
Precaution: INSUFFICIENT HUMAN DATA AVAILABLE
An adult over 60:
management or monitoring precaution: General-Monitor serum calcium closely. Increased risk of hypocalcemia with creatinine clearance less than 30 mL/min or on dialysis. Supplement calcium and vitamin D as needed. Musculoskeletal-Reports of atypical, pathologic subtrochanteric or proximal diaphyseal fractures can occur with little or no trauma.
Giving denosumab Solution to a child under 12:
Severe Precaution: Potential risk of impaired bone growth and tooth development. Limited use for giant cell tumor of bone in skeletally mature adolescents.