Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these medicines are used together, your liver processes both of them more quickly. Using them together also increases the risk of damage to your liver.
What might happen:
The amount of bosentan and glyburide in your blood may decrease and the medicines may not work as well. Your blood sugar may increase and your diabetes may not be as well controlled. Your liver could be damaged.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the medicine you use for your diabetes. Your doctor may run some blood tests to check your liver and your diabetes control. If you are having any headaches, nausea, vomiting, fever, unusual tiredness, abdominal pain, or yellowing of the skin or whites of your eyes, contact your doctor.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Tracleer (bosentan) US prescribing information. Actelion Pharmaceuticals US, Inc. October, 2012.
2.Diabeta (glyburide) US prescribing information. Sanofi-Aventis U.S. LLC October, 2013.