Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Atorvastatin may slow down how quickly your liver processes clopidogrel to its active form.
What might happen:
Your clopidogrel may not work as well or at all.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) about using these medicines together. Your doctor may want to check your blood to see if your clopidogrel is working. Your doctor may want to change your cholesterol medicine while you are taking clopidogrel.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Lau WC, Waskell LA, Watkins PB, Neer CJ, Horowitz K, Hopp AS, Tait AR, Carville DG, Guyer KE, Bates ER. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction. Circulation 2003 Jan 7;107(1):32-7.
2.Serebruany VL, Midei MG, Malinin AI, Oshrine BR, Lowry DR, Sane DC, Tanguay JF, SteinhublSR, Berger PB, O'Connor CM, Hennekens CC. Atorvastatin does not affect the antiplatelet properties of clopidogrel in patients undergoing coronary stenting in randomized data from the interaction of atorvastatin and clopidogrel (INTERACTION) trial. Presented at the 52nd Annual Scientific Session of the American College of Cardiology: Chicago, Illinois. March 30-April 2, 2003..