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Plavix

Interactions

Clopidogrel/Atorvastatin (mono deleted 03/21/2013)

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Atorvastatin may slow down how quickly your liver processes clopidogrel to its active form.

What might happen:

Your clopidogrel may not work as well or at all.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) about using these medicines together. Your doctor may want to check your blood to see if your clopidogrel is working. Your doctor may want to change your cholesterol medicine while you are taking clopidogrel.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Lau WC, Waskell LA, Watkins PB, Neer CJ, Horowitz K, Hopp AS, Tait AR, Carville DG, Guyer KE, Bates ER. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction. Circulation 2003 Jan 7;107(1):32-7.

2.Serebruany VL, Midei MG, Malinin AI, Oshrine BR, Lowry DR, Sane DC, Tanguay JF, SteinhublSR, Berger PB, O'Connor CM, Hennekens CC. Atorvastatin does not affect the antiplatelet properties of clopidogrel in patients undergoing coronary stenting in randomized data from the interaction of atorvastatin and clopidogrel (INTERACTION) trial. Presented at the 52nd Annual Scientific Session of the American College of Cardiology: Chicago, Illinois. March 30-April 2, 2003..

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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