If you are:
FDB Only When Necessary: BASED ON DRUG PHARMACOLOGY DEVELOPMENTAL TOXICITY IS POSSIBLE.
Absolute Contraindication: POTENTIAL SEVERE ADV EFFECTS INCLUDING BONE MARROW DEPRESSION,CARCINOGENICITY
An adult over 60:
management or monitoring precaution: General-Increased risk of myelosuppression, asthenia, gastrointestinal effects, infection, and alopecia. Renal-Adjust dose in renal impairment.
Giving Toposar Vial to a child under 12:
management or monitoring precaution: Anaphylactic reactions reported with IV use. Safety and efficacy not established.