Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
H-2 antagonists increase the pH (decrease the acidity) of your stomach. Atazanavir needs an acidic environment to be absorbed by your body.
What might happen:
The amount of atazanavir in your blood may decrease and it may not work as well against your HIV infection.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Discuss with your healthcare professional how you should take these medicines. Your doctor may want you to separate their administration times or may want to change the dose of your medicines. Your doctor may want to change your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Reyataz (atazanavir sulfate) Australian product information. Bristol-Myers Squibb Pharmaceuticals January 8, 2004.
2.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company March, 2015.