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Platinol AQ intravenous

Interactions

Cisplatin/Paclitaxel

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When cisplatin is given before paclitaxel, the beneficial effects of paclitaxel may be decreased. Cisplatin given before paclitaxel may also change how your body processes paclitaxel. This can result in an increase in its toxic effects.

What might happen:

When paclitaxel is given after cisplatin, the beneficial effects and how your body processes paclitaxel may change.

What you should do about this interaction:

If you experience a persistent sore throat or fever, contact your doctor as soon as possible. The dose of your medicines may need adjusting.When used together, paclitaxel is usually given before cisplatin or at the same time. Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dose of any medicine before checking with them first.

References:

1.Liebmann JE, Fisher J, Teague D, Cook JA. Sequence dependence of paclitaxel (Taxol) combined with cisplatin or alkylators in human cancer cells. Oncol Res 1994;6(1):25-31.

2.Taxol (paclitaxel) US prescribing information. Bristol-Myers Squibb Company August, 2010.

3.Jekunen AP, Christen RD, Shalinsky DR, Howell SB. Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro. Br J Cancer 1994 Feb;69(2):299-306.

4.Vanhoefer U, Harstrick A, Wilke H, Schleucher N, Walles H, Schroder J, Seeber S. Schedule-dependent antagonism of paclitaxel and cisplatin in human gastric and ovarian carcinoma cell lines in vitro. Eur J Cancer 1995;31A(1):92-7.

5.Rowinsky EK, Gilbert MR, McGuire WP, Noe DA, Grochow LB, Forastiere AA, Ettinger DS, Lubejko BG, Clark B, Sartorius SE, et al. Sequences of taxol and cisplatin: a phase I and pharmacologic study. J Clin Oncol 1991 Sep; 9(9):1692-703.

6.Clark JW, Santos-Moore AS, Choy H. Sequencing of taxol and carboplatimum therapy. Proc Am Assoc Cancer Res 1995 Mar;36:298.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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