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Inherited Blood-Clotting Problems - Topic Overview

Some people are born with an increased tendency to form blood clots, which increases their risk for developing blood clots in the legs (deep vein thrombosis) and in the lungs (pulmonary embolism). This tendency is due to inherited blood-clotting irregularities, which are generally related to:

  • Mutated genes (such as factor V Leiden, factor II).
  • Decreased amounts of certain proteins (protein C, protein S, and antithrombin III).
  • Increased levels of other substances (antiphospholipid or lupus anticoagulant).

Many of these blood-clotting irregularities can be identified with special tests. If your doctor suspects that you may have an inherited blood-clotting irregularity, discuss whether testing is needed.

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    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Medical Reference from Healthwise

    Last Updated: March 12, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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