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Inherited Blood-Clotting Problems - Topic Overview

Some people are born with an increased tendency to form blood clots. This makes them more likely to get blood clots in the legs (deep vein thrombosis) and in the lungs (pulmonary embolism). This tendency is due to inherited blood-clotting problems, which are often related to:

  • Mutated genes (such as factor V Leiden, factor II).
  • Decreased amounts of certain proteins. These may include protein C, protein S, and antithrombin III.
  • Increased levels of other substances. These may include antiphospholipid and lupus anticoagulant.

Many of these blood-clotting irregularities can be found with special tests. If your doctor suspects that you may have an inherited blood-clotting problem, discuss whether you need testing.

Recommended Related to DVT (Deep Vein Thrombosis)

Pulmonary Embolism: A Complication of DVT

A pulmonary embolism (PE) usually happens when a blood clot called a deep vein thrombosis (DVT), often in your leg, travels to your lungs and blocks a blood vessel. That leads to low oxygen levels in your blood. It can damage the lung and other organs and cause heart failure, too. A PE can be life-threatening, so if you've been diagnosed with DVT, you should be aware of this risk. Follow the treatment plan for your DVT to stop the clot from getting bigger and to keep new clots from forming.

Read the Pulmonary Embolism: A Complication of DVT article > >

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Medical Reference from Healthwise

    Last Updated: September 09, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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