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Inherited Blood-Clotting Problems - Topic Overview

Some people are born with an increased tendency to form blood clots. This makes them more likely to get blood clots in the legs (deep vein thrombosis) and in the lungs (pulmonary embolism). This tendency is due to inherited blood-clotting problems, which are often related to:

  • Mutated genes (such as factor V Leiden, factor II).
  • Decreased amounts of certain proteins. These may include protein C, protein S, and antithrombin III.
  • Increased levels of other substances. These may include antiphospholipid and lupus anticoagulant.

Many of these blood-clotting irregularities can be found with special tests. If your doctor suspects that you may have an inherited blood-clotting problem, discuss whether you need testing.

Recommended Related to DVT (Deep Vein Thrombosis)

What Causes Deep Vein Thrombosis (DVT)?

Deep vein thrombosis (DVT) is a blood clot that forms in a vein inside a muscle. It usually happens in your legs, but you can also get them in your arms, chest, and other areas of your body. It can be serious. It may make your leg hurt and swell. The clot might move and get stuck in a blood vessel in your lungs, brain, or heart. That could cause organ damage and even death -- within hours. The main cause of DVT is poor blood flow. When it slows, blood can pool, which gives the cells a chance...

Read the What Causes Deep Vein Thrombosis (DVT)? article > >

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Medical Reference from Healthwise

    Last Updated: September 09, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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