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This article is from the WebMD News Archive
Nightly Viagra May Restore Normal Erections
May 13, 2004 -- When men with erectile dysfunction take Viagra every night, rather than just when the mood strikes them, they may experience a return to normal erections, say researchers at a meeting of men's health specialists.
"Nightly treatment may help promote erectile function as the result of this drugs' beneficial effect on endothelial cells," Frank Sommer, MD, said in a news conference. Endothelial cells line the walls of the blood vessels. Erections occur when the blood vessels in the penis dilate and fill with blood. Sommer, chief of andrology in the department of urology at the University of Cologne in Cologne, Germany, presented his findings at a meeting of the American Urological Association.
Normal Erections Without Erectile Dysfunction Treatment
He and his co-investigators studied 76 men who had erectile dysfunction for at least six months. Group 1 took 50 mg of Viagra nightly at bedtime. Group 2 took 50-100 mg of Viagra when they wanted, presumably before sexual intercourse. The investigators also followed a third group of men with erectile dysfunction who received no treatment. The men were an average of 47 years old.
After 12 months of nightly Viagra followed by one month of no erectile dysfunction treatment, nearly 60% of men in group 1 had a return of normal erections. Less than 10% of men that took Viagra as needed had a similar return of normal erections.
At the end of a six-month period without any erectile dysfunction treatment, all but one of the men in group 1 still had normal erections. Normal erections were determined by an erectile function questionnaire completed by the men.
Researchers also measured blood flow to the penis. After one month of no erectile dysfunction treatment, group 1 had a significant improvement in blood flow. However, group 2 had no significant change and blood flow, and group 3 worsened.
"This is the only study we know of that has investigated the long-term effects of taking erection-promoting therapy on a daily basis," Sommer says. "After only one year, [Viagra] taken regularly at bedtime may be ... a useful tool for curing erectile dysfunction."
"This data should encourage researchers to explore this issue further," John P. Mulhall, MD, tells WebMD.
"Erections are good for your penis, and probably good for mental health. Taking medication for erections may also be good for a man's overall health. This is the first study to look at long-term treatment to improve erectile function in men, but the sample is too small to definitively answer the question. We really need a big study with a long follow-up to know the answers." Mulhall, who was not involved in the study, is an associate professor and director of sexual medicine in the departments of urology at Weill Medical College of Cornell University and Memorial Sloan-Kettering Cancer Center in New York.
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Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.
