Fibromyalgia is a perplexing and often debilitating disorder, but treatment can help. Lyrica, a medicine used to treat patients with seizures, pain from shingles, and nerve pain from diabetes and spinal cord injuries, is offering new hope to those living with the pain of fibromyalgia. Here is what you need to know about the use of Lyrica to manage fibromyalgia, from the drug's benefits to its side effects.
Fibromyalgia is a common condition that causes painful muscles. The pain is severe and involves many muscles as well as tendons, ligaments, and other soft tissue areas. Fibromyalgia has also been linked to fatigue, sleep problems, headaches, cognitive dysfunction, depression, and anxiety.
Irritable bowel syndrome (IBS) is a disorder that involves abdominal pain, cramping, bloating, as well as changes in bowel movements - constipation or diarrhea, or alternation of both. People with IBS often experience anxiety and depression.
Millions of people have at least one of these conditions. Fibromyalgia affects 5 million U.S. adults, and an estimated 25 million to 45 million people in the U.S. have IBS.
If you have fibromyalgia or IBS, you may be more likely to have the other one, too.
In one study, 32% of people with IBS also had fibromyalgia symptoms, compared with 4% of people without IBS. Another study showed fibromyalgia occurring in 20% of people with IBS. And studies have estimated 32% to 70% of people with fibromyalgia also meet criteria for IBS.
Linked but Separate
The root causes of fibromyalgia and IBS are not clear; both are functional disorders, which means there's nothing visibly wrong with the structure of the organs but with how they work.
But there is relationship between two, says Michael J. Pellegrino, MD, a fibromyalgia expert at Ohio Pain and Rehab Specialists in North Canton, Ohio, and an expert on WebMD's Fibromyalgia Exchange. Pellegrino, who has fibromyalgia, says he also has intermittent IBS that he considers mild.
“There’s some connection because they come in clusters, but we don’t know what it is right now,” says Albena Halpert, MD, an assistant professor of gastroenterology at Boston University's medical school.
Researchers see a possible pain link between IBS and fibromyalgia. In short, people with those conditions respond to pain differently than people without the two conditions.
IBS patients are hypersensitive to intestinal pain; people with fibromyalgia are hypersensitive to skin and muscle pain. There is a lowered threshold to pain sensation in general, Halpert says.
It’s been also found that people with these conditions respond favorably to a certain group of antidepressants, which suggests they share a similar underlying cause.
In fibromyalgia, the central nervous system may be highly sensitive, making someone feel more pain than what someone without fibromyalgia would feel in a similar situation. And the central nervous system is not as able to block or inhibit the pain compared to someone without the condition, Pellegrino says.
In IBS, someone has the urge to pass a bowel movement that is often associated with bowel cramping, and the body fails to curb those pain signals. Similarly, a very mild trigger -- such as certain foods that don't bother most people -- can result in cramping someone with IBS, Halpert says.