Dec. 3, 2009 -- Half of patients treated in intensive care units around the
globe have infections and more than two out of three are treated with
antibiotics, according to a new study.
The findings raise concerns about the effectiveness of efforts to reduce
hospital-acquired infections worldwide, experts tell WebMD.
The study included data from nearly 14,000 adult patients treated at nearly
1,300 ICUs in 75 countries.
Just as they had done twelve years earlier, researchers recorded the
prevalence of infections and antibiotic treatment among the ICU patients during
a single day in 2007.
Fifty-one percent of ICU patients had infections and 71% were being treated
with antibiotics, compared to 45% and 62%, respectively, in the 1995
The new research appears in this week's edition of The Journal of the
American Medical Association.
"It is clear the frequency of infections in intensive care
units is increasing, but this is due to a number of factors," study researcher
Jean-Louis Vincent, MD, PhD, of Brussels, Belgium's Erasme Hospital tells
"We are treating more patients who are older and sicker and who are on
immunosuppressive therapies. These patients are more likely to enter hospitals
with infections. But despite all of our efforts, it is also clear we need to do
more to prevent [hospital-acquired] infections."
Infected patients were more than twice as likely to die while still being
treated in the ICU than non-infected patients (25% vs. 11%).
Respiratory infections were most common, accounting for 64% of all
infections reported. Other infection sites included the abdomen (20%), the
bloodstream (15%), and urinary tract (14%).
Infection rates were higher among patients with longer ICU stays: 32% of
patients hospitalized in the ICU for no more than one day were infected
compared to 70% of patients treated in ICUs for more than a week.
Central and South America had the highest overall infection rates (60%) of
the countries included in the study, while Africa had the lowest (46%). The
single-day infection rates in North America and Western Europe were 48% and