Atherosclerosis is a condition in which cholesterol, fat, calcium, and other substances build up in the walls of your arteries. This buildup is called "plaque." Plaque clogs your arteries, causing them to become narrow, which makes it difficult for blood to flow. Atherosclerosis raises your risk of heart attacks and strokes. If the condition involves the arteries in your legs, it is called peripheral artery disease. Follow the links below to find WebMD's comprehensive coverage about how atherosclerosis develops, what it looks like, how to treat it, and much more.