Heart Failure: Compensation by the Heart and Body - Topic Overview
Heart failure means that your heart muscle doesn't pump as much blood as your body needs. Because your heart cannot pump well, your heart and your body try to make up for it. This is called compensation.
Your body has a remarkable ability to compensate for heart
failure. The body may do such a good job that many people don't feel symptoms in the earlier stages of heart failure. It is only when your
body isn't able to compensate enough that you will begin to experience
Jim Dearing of Louisville, Ky., one of the first men in the world to receive heart stem cells, might have helped start a medical revolution that could lead to a cure for heart failure.
Three years after getting the experimental stem cell procedure, following two heart attacks and heart failure, Dearing’s heart is working normally.
The difference is clear and dramatic -- and it's lasting, according to findings now being made public for the first time.
Dearing first showed "completely normal heart...
Compensation may help your body adjust to the effects of
heart failure in the short term. But over time
it can make heart failure worse by further enlarging the heart and
reducing the pumping ability of the heart.
How does the body compensate?
With heart failure, the heart doesn't pump as well as it should. So your body doesn't get enough blood and oxygen. When this occurs, the body believes
that there isn't enough fluid inside its vessels. The body's hormone and
nervous systems try to make up for this by increasing blood
pressure, holding on to salt (sodium) and water in the body, and increasing
heart rate. These responses are the body's attempt to compensate for the poor
blood circulation and backup of blood.
The nervous system. If your body senses
that the brain and vital organs aren't receiving enough blood, the sympathetic nervous system starts working to get more blood to your brain and organs. This system
releases substances called
catecholamines into the bloodstream. These substances
cause the blood vessels to constrict and speed up the heart rate. At the same time, the arteries supplying the brain and vital organs
widen to carry the increased blood flow.
Hormone systems. When the body thinks it needs more
fluid in its blood vessels, it releases specific chemicals (renin, angiotensin,
and aldosterone) that cause the blood vessels to constrict. In addition, these
hormones cause the body to retain more sodium and water. This adds fluid to your circulatory system. This fluid becomes part of the blood
circulating throughout your system.
How does the heart compensate?
Your heart's goal in compensating for
heart failure is to maintain your cardiac output.
Cardiac output is the amount of blood your heart is able to pump in 1 minute.
The problem in heart failure is that the heart isn't pumping out enough blood
each time it beats (low stroke volume). To maintain your cardiac output, your
heart can try to:
Beat faster (increase your heart
Pump more blood with each beat (increase your stroke
How does the heart know to beat faster? Your
brain signals your heart to beat faster by sending messages to your heart's
electrical system, which controls the timing of your heartbeat. When your
cardiac output is low, your adrenal glands also release more norepinephrine
(adrenaline), which travels in the bloodstream and stimulates your heart to
beat faster. Although beating faster helps to maintain cardiac output as the
stroke volume falls, a faster heart rate can be counterproductive because it
allows less time for the ventricle to fill with blood after each heartbeat.
Also, a very fast heart rate can itself weaken the heart muscle over time.
How does the heart increase its stroke volume? To increase its stroke volume, your heart can try to:
Get more blood into your heart. If your left ventricle isn't doing a good job pumping blood out,
your heart can try to compensate by allowing more blood to fill the ventricle
before it pumps by expanding its size (dilating) to increase its volume. This
form of compensation may be helpful at first, but as the heart gets bigger and
bigger, there is more and more tension on the walls of the heart to pump out
the blood inside it. This increases the strain on the heart, making its
function worse over time.
Your heart can pump harder by developing stronger, thicker muscle. This
thickening of your heart muscle is called hypertrophy, and it can help your
heart pump more forcefully and increase your stroke volume. But
hypertrophy of the heart muscle increases the heart's need for oxygen and other
nutrients. These requirements can eventually outstrip the blood supply to the
heart, leading to further weakening of the heart muscle. In addition,
hypertrophy of the walls of the heart can make diastolic function worse by
impairing the ability of the heart to relax properly. This limits the heart's
ability to fill with blood, which can also further reduce cardiac