You probably will need to take a combination of medicines to treat heart failure, even if you do not have symptoms yet. Medicines do not cure heart failure. However, they can help you manage your symptoms.

The goals of drug treatment are to relieve or control symptoms of heart failure, improve daily function and quality of life, slow the progression of the disease, and reduce the risk of complications, hospital stays, and premature death.

Medicines are used to treat the problems associated with heart failure, including:

• Fluid buildup, swelling, and water retention (edema).
• The reduced pumping ability of the heart.
• The effects of the body's attempt to compensate for heart failure.
• Underlying conditions that can lead to heart failure, such as coronary artery disease, high blood pressure, or diabetes.
• Prevention of complications, such as stroke.

It is extremely important that you take your medicines exactly as recommended by your doctor. If you don't, your heart failure may get worse or you may develop sudden heart failure. For more information, see:

Taking your medicines properly when you have heart failure.

Medicine Choices

A combination of medicines is often needed to control symptoms and slow the progression of heart failure. Some medicines are used to treat pumping problems (systolic heart failure), and others are used to treat problems with filling (diastolic heart failure). The most commonly used and effective classes of medicines are as follows:

Medicines for pumping problems (systolic heart failure)

These include:

• ACE inhibitors (angiotensin-converting enzyme inhibitors). ACE inhibitors allow blood vessels to relax and widen (dilate), making it easier for blood to flow through the vessels.
• ARBs (angiotensin II receptor blockers). Like ACE inhibitors, ARBs allow blood vessels to relax and widen (dilate), making it easier for blood to flow through the vessels.
• Diuretics. Diuretics stimulate the kidneys to remove more water and salt (sodium) from the body.
• Aldosterone receptor antagonists. These medicines cause the kidneys to get rid of extra salt and fluid, and they help hold on to (retain) potassium by inhibiting the action of the hormone aldosterone.
• Digoxin. Digoxin slows and strengthens heart contractions, enabling the heart to pump more blood with each beat.
• Beta-blockers. Beta-blockers control symptoms of heart failure by either slowing the heart rate or making the blood vessels wider so blood flows more easily.
• Vasodilators. Vasodilators lower blood pressure and reduce the workload on the heart.

A new medicine called BiDil significantly decreases death rates in African Americans who have advanced heart failure, according to the first major trial to test a drug only in African Americans. BiDil is a combination of hydralazine and isosorbide, two older drugs that have been used in the past to treat various heart conditions. When taken along with standard medicines for heart failure, BiDil was found to decrease the number of hospital stays and increase survival rate.¹²

Medicines for filling problems (diastolic heart failure)

• Beta-blockers
• Diuretics
• ACE inhibitors
• ARBs (angiotensin II receptor blockers)
• Calcium channel blockers
• Direct renin inhibitors