Hepatitis C treatments have changed a lot in recent years. In January 2016, the FDA gave approval to a once-daily pill combination of elbasvir and grazoprevir called Zepatier. It has been shown to have the ability to cure the disease in almost 100% of those treated. It follows the success of another once-daily treatment called Harvoni that cures the disease in most people in 8-12 weeks. Harvoni combines two drugs: sofosbuvir (Sovaldi) and ledipasvir. In clinical trials, the most common side effects in both drugs were fatigue and headache.