Hepatitis C is the No. 1 cause of liver cancer and liver transplants. It's brought on by a virus you can catch if you come into contact with contaminated blood. You could get it from an unclean tattoo needle, for example. Sometimes, it spreads during sex.
It's curable. But curing it hasn't always been easy or comfortable. For decades, you needed painful shots of a medicine called interferon and a pill called ribavirin. These drugs didn't target the virus that made you sick. Instead, they amped up your immune system so you'd fight it the way you do when you get the flu.
But the treatment didn't always get the virus out of your body. Cure rates hovered around 50%. And people who stuck with the yearlong treatment -- not all did -- had to live with chemo-like side effects.
These days, more and more people can get rid of the virus by simply taking a pill, at home, for just a few weeks. There are several ways to do it without having to get shots.
Here's a closer look at some of the drugs and a peek at those on the horizon.
How They Work
There's no one-size-fits-all option. There are many different types, or "genotypes," of hepatitis C. Type 1 is the most common. This is important to understand when you talk to your doctor. Not all meds work on all types. Which medicine is best for you also depends on how much liver scarring (cirrhosis) you have.
Your doctor might call these new drugs direct-acting antivirals. They zoom in on the virus that's making you sick. Each drug works in a slightly different way. But in general, the medicine interferes with proteins that help the virus grow or spread.
Most of the time, these meds remove all traces of the virus from your blood within 12 weeks. This is called sustained virologic response (SVR), and it’s what doctors look for to tell if you’re cured. How long you'll need treatment can vary. It may range from 8 to 24 weeks.
Today's Meds
Research is moving rapidly on treatments for hep C. As a result, what doctors will recommend for each case may change. Researchers may continue to come up with new treatments, and some of the combinations of medications below may change as they make new discoveries.
Hepatitis C is a contagious
liver disease caused
by the Hepatitis C virus,
or HCV.
If your immune system isn't
able to fight off the infection
naturally, you may need
treatment.
HCV is treated
with oral medications called
direct antiviral agents,
or DAAs.
The exact medicine you take
depends on the type of hep C you
have, how damaged your liver is,
and other treatments you've had.
DAAs work by stopping
the hepatitis C virus
from making copies of itself.
In this way, DAAs cure over 90%
of people in about 12 weeks.
During that time,
you'll see your doctor regularly
to check for side effects
and review your lab tests.
Three months
after your treatment ends,
your doctor will test your blood
for HCV.
If the virus isn't found,
you've been cured,
and you'll likely
be virus-free for the rest
of your life.
But remember: while you may be
cured, you're not immune to HCV
and could become infected again.
Continued
As always, it's best to discuss your treatment options with your medical team.
Daclatasvir (Daklinza): Approval of this drug meant no more shots for the 1 in 10 people infected with hepatitis C virus (HCV) types 1 and 3. You take this pill once a day with sofosbuvir (Sovaldi). You might get a headache or feel a little tired. Tell your doctor if you feel super-sluggish. The FDA warns it can sometimes seriously slow your heart rate, which may require you to get a pacemaker.
Elbasvir and grazoprevir (Zepatier): This once-a-day pill treats HCV types 1 and 4. It may also offer new hope for people with hep C who also have cirrhosis, HIV, late-stage kidney disease, and other hard-to-treat conditions. Like the other antivirals, the side effects are mild. You might have a slight headache or bellyache, or you might feel tired.
Glecaprevir and pibrentasvir (Mavyret): Three pills daily can treat all types of hep C. Side effects are mild and can include headache, fatigue, diarrhea, and nausea.
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Ledipasvir and sofosbuvir (Harvoni): This once-a-day pill launched a revolution in hep C treatment. It was the first interferon-free med for people with type 1. A year later, the FDA also gave the thumbs up for people with HCV types 4, 5, and 6 to use it. Side effects are mild. You might feel tired or have a slight headache. Some people have a bellyache, diarrhea, and trouble sleeping.
Ombitasvir, paritaprevir, and ritonavir, with dasabuvir (Viekira Pak):Doctors say this treatment works well for people with HCV type 1. You can even take it if you have some liver scarring, as long as your liver still can do its job. Your doctor might call this compensated cirrhosis. You take two pills once a day and another pill twice a day.
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Some people find this clunky, but others say it beats getting shots. Side effects include feeling itchy, weak, tired, or having trouble sleeping. This medicine might cause severe liver damage in people with advanced cirrhosis.
Hepatitis C is a contagious
liver disease caused
by the hepatitis C virus,
or HCV.
In some cases, the virus causes
a long-lasting infection.
When that happens, inflammation
from the infection
slowly damages your liver
over time.
Healthy liver cells die and are
replaced with scarring called
cirrhosis.
As the scar tissue grows,
your liver has less healthy
tissue.
This makes it
hard for your liver to clean
your blood, help with digestion,
and store energy
your body needs.
Damage to your liver
can cause heavy bleeding,
swelling, and breathing
problems.
Cirrhosis also makes it likely
that you will get infections,
and it can raise your odds
of getting liver cancer.
If left untreated,
the scar tissue grows
until your liver can't work
the way it should.
At this stage, liver failure
can happen.
For more information
about treatments that can help,
talk to your doctor.
Continued
Simeprevir (Olysio)and sofosbuvir (Sovaldi):The FDA said these two drugs could be given together to treat people with HCV type 1. Before that, you had to take the pills with interferon or ribavirin. Sofosbuvir can cause fatigue, headache, and tummy troubles and make it hard for you to sleep. Simeprevir may cause dry skin and a rash and make you more sensitive to sunlight.
Sofosbuvir and velpatasvir(Epclusa):This can treat all types of hep C with a single tablet. Common side effects are headache and fatigue. There are certain drugs that shouldn't be taken with it, as the combination can slow your heartbeat. As always, check with your doctor.
Sofosbuvir, velpatasvir, and voxilaprevir (Vosevi):This can also treat all types of hep C with one tablet that you take each day. Typically, your doctor will only prescribe this if you don't have cirrhosis and after other treatments have not worked. The most common side effects are headache, tiredness, diarrhea, and nausea.