Air Pollution Linked to Heart Problems, Deaths
March 20, 2000 (Eugene, Ore.) -- Ozone and fine particles of matter in the
air appear to lower the human heart's ability to vary its speed, resulting in
increased heart attacks and heart-related deaths, according to researchers from
Harvard Medical School in Boston.
"The heart's ability to vary its speed is valuable because it lets us
respond quickly to changing requirements," says Ronald White, assistant
vice president for national policy of the American Lung Association.
"People intuitively understand that air pollution can affect the lungs, but
now we're finding that it also affects other organs, especially the
Many studies have previously found an association between episodes of air
pollution and increases in both heart attacks and deaths due to heart-related
causes. "The unanswered question has been, what is the mechanism behind
this association?" says Diane Gold, MD, MPH, co-author of the study. Gold
is an assistant professor of medicine at Harvard Medical School's Brigham and
Women's Hospital in Boston.
Michael Lauer, MD, says, "It's not easy to measure exactly how much air
pollution any particular person gets, because the exposure is diluted.
Cigarette smoking in comparison is a direct exposure, like being hit with a
jackhammer; air pollution is similar to being surrounded by a fishing net."
Lauer is director of the exercise laboratory and staff cardiologist at the
Cleveland Clinic Foundation.
The Harvard researchers asked 21 people to come in for a series of half-hour
observation periods. They wore a device permitting continuous monitoring of
their heart rate and other key measures while going through five minutes of
rest, then standing, exercise, and slow breathing. This allowed researchers to
see how quickly their hearts responded to changes in activities.
Researchers found that on days with high levels of fine particles and ozone,
the subjects had reduced heart rate variability. Other pollutants such as
carbon dioxide were not associated with declines in heart rate variability.
The fine particles that seem to be one source of the problem are extremely
small, less than 2.5 microns in diameter. (For comparison, a human hair is
about 75 microns in diameter.) According to White, the major sources of these
particles are diesel trucks and buses, off-road equipment such as construction
equipment, and smokestack gases that may travel from hundreds of miles
"This is one of a series of studies looking at heart rate variability,
and probably the most comprehensive one that's been published to date,"
says Daniel Greenbaum, president of the Health Effects Institute in Boston.
"One key question this study doesn't fully answer is whether this should
concern those who do not have preexisting heart or lung disease." The
Health Effects Institute is a nonprofit organization partially funded by the
Environmental Protection Agency (EPA). Greenbaum is a member of the National
Research Council's Committee on Research Priorities for Airborne Particulate