Testosterone Use for Aging Questioned
Mayo Clinic Study Shows Little Known About Risks, Benefits
WebMD News Archive
Jan. 19, 2007 -- A growing number of middle-aged and elderly men are using
testosterone creams, gels, and patches in an effort to feel young again, but
there is little evidence the treatments are either effective or safe.
That is the conclusion of investigators from the Mayo Clinic who conducted
two research analyses of testosterone therapy.
The studies they reviewed examined the risks from such treatment for heart disease
and stroke and the benefits
for boosting sexual function.
The researchers found that far too few quality studies have been published
to accurately assess the treatment's safety and usefulness.
"Patients and their physicians should be able to make therapeutic
decisions with a clear idea of what the risks and benefits are, but in this
case that isn't possible," researcher Victor M. Montori, MD, MSc, tells
WebMD. "There is still a lot of uncertainty about this treatment."
Roughly 2.4 million prescriptions for testosterone were filled in the U.S.
in 2004 -- more than twice the number filled just four years earlier, according
to pharmaceutical sales figures.
Such treatment has clear benefits for men with very low testosterone levels,
often caused by surgical or chemical castration (using a drug to block
production of testosterone in the body).
But the benefits of boosting testosterone levels in otherwise healthy agingmen experiencing natural declines in hormone levels are not as well
Backers of the treatment say it can increase energy, libido, and general
well-being; promote muscle growth; and protect against heart disease and bone
On the flip side, there are suggestions that testosterone treatment may
actually increase a man's risk of heart disease as well as prostate cancer
and benign prostate growth.