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    Testosterone Use for Aging Questioned

    Mayo Clinic Study Shows Little Known About Risks, Benefits

    Analyzing the Risks

    Montori and colleagues in two different analyses reviewed studies examining the impact on sexual dysfunction and risk for heart diseaseand stroke.

    Small to moderate improvements were seen in erectile function and libido, but the researchers concluded the sexual studies were inconsistent.

    They also found the studies examining risk for heart disease and stroke to be lacking, saying large trials of men at risk for cardiovascular disease are needed.

    "We have a situation where physicians and patients are essentially in the same boat," Montori says. "Neither is fully informed about testosterone therapy, because the long-term research just hasn't been done."

    The researchers' reviews are published in the January issue of the journal Mayo Clinic Proceedings.

    The Lesson of Estrogen

    Better studies are urgently needed, Montori says, to avoid repeating what he calls "the estrogen disaster."

    Millions of women took estrogen to protect against a wide range of diseases associated with aging, until a major study linked estrogen's use by older women to an increased risk of heart disease and breast cancer.

    "I would contend that the quality of the evidence that we have about the safety and efficacy of testosterone therapy is much weaker than the evidence that we had when we were prescribing estrogen for just about everything," he says.

    In a review of the research published late in 2003, an expert panel convened by the Institute of Medicine also found little evidence of the effectiveness and long-term safety of testosterone therapy in healthy, aging men.

    That group called for large studies designed to examine the risks and benefits of testosterone therapy for such men.

    Dan G. Blazer, MD, of Duke University, who lead the panel, tells WebMD we know little more about these risks and benefits today than we did three years ago.

    "We don't have a clear picture of side effects, so we can't say that this drug is dangerous," he says.

    "But, on the other hand, we don't have a lot of evidence that it is effective," says Blazer. "My concern is that its use as an antiaging drug will explode before we have the answers."

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