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Substance Abuse and Addiction Health Center

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Antidote for Prescription Painkiller Overdose OK'd

Evzio is part of efforts to stem health risks from abuse of drugs such as Oxycontin, Vicodin

WebMD News from HealthDay

By Dennis Thompson

HealthDay Reporter

THURSDAY, April 3, 2014 (HealthDay News) -- People suffering a potentially fatal narcotic overdose now can receive lifesaving treatment from folks around them, using a new device just approved by the U.S. Food and Drug Administration.

Evzio is a hand-held auto injector that delivers a single dose of the drug naloxone into the muscle or beneath the skin. The injector can be carried in a pocket or stored in a medicine cabinet and is meant as an emergency treatment for people who have suffered a known or suspected overdose of powerful pain drugs called opioids.

Opioids include prescription narcotic painkillers such as Oxycontin, Vicodin and Percocet -- all of which have shown increasing rates of abuse in recent years.

They also include the illicit drug heroin, which has increased in popularity and recently led to the death of actor Philip Seymour Hoffman.

The Obama administration is urging all local police and fire departments to equip their officers and vehicles with Evzio, Michael Botticelli, acting director of the White House Office of National Drug Control Policy, said at a Thursday news conference.

Family members and friends of people who are struggling with narcotics addiction or are taking opioids for a medical condition also will be able to equip themselves with Evzio, just by getting a prescription from their physician.

"A family member of someone at risk for opioid overdose could receive a prescription," said Dr. Douglas Throckmorton, deputy director for regulatory programs at the FDA's Center for Drug Evaluation and Research. "Physicians can prescribe to anyone concerned about the risks of possible opioid overdose."

The product is built to be simple and easy-to-use for lay people, FDA Commissioner Dr. Margaret Hamburg said at the news conference.

Naloxone rapidly reverses the effects of overdose and is the standard treatment in such cases. However, current naloxone drugs have to be injected with a needle and their use is typically limited to trained medical personnel, the FDA explained.

Once the device is turned on, it provides verbal instructions on how to deliver the medication, similar to how an automatic heart defibrillator works.

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