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    Schilder's Disease: Children & Multiple Sclerosis

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    What is Schilder's Disease?

    Note: Schilder's disease is not the same as Addison-Schilder disease (adrenoleukodystrophy). Schilder's disease is a rare progressive demyelinating disorder which usually begins in childhood. Symptoms may include dementia, aphasia, seizures, personality changes, poor attention, tremors, balance instability, incontinence, muscle weakness, headache, vomiting, and vision and speech impairment. The disorder is a variant of multiple sclerosis.

    Is there any treatment?

    Treatment for the disorder follows the established standards in multiple sclerosis and includes corticosteroids, beta-interferon or immunosuppressive therapy, and symptomatic treatment.

    What is the prognosis?

    As with multiple sclerosis, the course and prognosis of Schilder's disease are unpredictable. For some individuals the disorder is progressive with a steady, unremitting course. Others may experience significant improvement and even remission. In some cases, Schilder's disease is fatal.

    What research is being done?

    The NINDS supports and conducts an extensive research program on demyelinating disorders such as Schilder's disease. Much of this research focuses on learning more about these disorders and finding ways to prevent, treat, and cure them.


    National Multiple Sclerosis Society
    733 Third Avenue
    6th Floor
    New York, NY 10017-3288
    Tel: 212-986-3240 800-344-4867 (FIGHTMS)
    Fax: 212-986-7981

    Multiple Sclerosis Association of America
    706 Haddonfield Road
    Cherry Hill, NJ 08002
    Tel: 856-488-4500 800-532-7667
    Fax: 856-661-9797

    Multiple Sclerosis Foundation
    6350 North Andrews Avenue
    Ft. Lauderdale, FL 33309-2130
    Tel: 954-776-6805 888-MSFOCUS (673-6287)
    Fax: 954-351-0630

    Related NINDS Publications and Information

    Multiple Sclerosis: Hope Through Research

    Multiple Sclerosis (MS) information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).

    WebMD Public Information from the U.S. National Institutes of Health

    Reviewed on January 25, 2006
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