Schilder's Disease: Children & Multiple Sclerosis
What is Schilder's Disease?
Note: Schilder's disease is not the same as Addison-Schilder disease
(adrenoleukodystrophy). Schilder's disease is a rare progressive demyelinating
disorder which usually begins in childhood. Symptoms may include dementia,
aphasia, seizures, personality changes, poor attention, tremors, balance
instability, incontinence, muscle weakness, headache, vomiting, and vision and
speech impairment. The disorder is a variant of multiple sclerosis.
Is there any treatment?
Treatment for the disorder follows the established standards in multiple
sclerosis and includes corticosteroids, beta-interferon or immunosuppressive
therapy, and symptomatic treatment.
What is the prognosis?
As with multiple sclerosis, the course and prognosis of Schilder's disease
are unpredictable. For some individuals the disorder is progressive with a
steady, unremitting course. Others may experience significant improvement and
even remission. In some cases, Schilder's disease is fatal.
What research is being done?
The NINDS supports and conducts an extensive research program on
demyelinating disorders such as Schilder's disease. Much of this research
focuses on learning more about these disorders and finding ways to prevent,
treat, and cure them.
National Multiple Sclerosis Society
733 Third Avenue
New York, NY 10017-3288
Tel: 212-986-3240 800-344-4867 (FIGHTMS)
Multiple Sclerosis Association of America
706 Haddonfield Road
Cherry Hill, NJ 08002
Tel: 856-488-4500 800-532-7667
Multiple Sclerosis Foundation
6350 North Andrews Avenue
Ft. Lauderdale, FL 33309-2130
Tel: 954-776-6805 888-MSFOCUS (673-6287)
Related NINDS Publications and Information
Multiple Sclerosis: Hope Through Research
Multiple Sclerosis (MS) information sheet compiled by the National
Institute of Neurological Disorders and Stroke (NINDS).