Medical Advances and Breakthroughs
Mood-Lifting Implants continued...
In studies of DBS, half the patients have experienced at least a 50 percent improvement in mood, and a third have had complete remission — unusual success for treatment-resistant depression. "You just don't get these kinds of results in these patients," says study coauthor Emad N. Eskander, M.D., associate professor of surgery at Harvard Medical School. The procedure is still experimental, though final trials for FDA approval are under way and it could be available within a few years.
Schaefer was among the lucky ones. "I used to cry every day," she says. But after her pacemaker was turned on, her sadness gradually lifted. She no longer has trouble finding her way around town, and has returned to church, where she cochairs the trustee committee. She is filling in her missing memories by creating scrapbooks for her daughters and other family members.
Every six months or so, Schaefer has to have the batteries in the chest unit replaced — surgery done under general anesthesia. But, weighing where she was before and what her life offers her now, she says it's not a big deal: "For 34 years I was fighting just to stay alive." Even with the pain and inconvenience, she says, "this is the best thing that's ever happened to me and my family."
When a person's heart stops beating, no blood — and no oxygen — is going to the brain. Cooling the body a few degrees reduces the chance of damage, increasing the odds that the patient will return to a normal life. That's why accident victims who live through a plunge into a freezing river can survive without neurological problems. But in a hospital, the processes that are used to cool bodies — blowing cold air on patients, or packing them in ice — can take hours, often too long to stop cell death and brain damage. It's no wonder only a small fraction of cardiac arrest patients whose hearts are restarted regain all their abilities.
"If the stars hadn't fallen in line on November 11, 2008," as Cynthia Crawford, 57, puts it, she might not have been in that lucky group. A former psychiatric nurse in Baton Rouge, LA, and a mother of four, Crawford was at New Orleans's Ochsner Medical Center for tests to see if she was a candidate for a heart transplant. A former smoker who suffered from congestive heart failure, Crawford was using a pacemaker and an implanted defibrillator to keep her heart pumping. But it was growing weak. When a medical resident found her slumped in the hospital garage, he quickly rushed her to the ER.