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Cryotherapy for Prostate Cancer Treatment

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Cryotherapy uses extremely cold temperatures to freeze and destroy cancer tissue in the prostate. There are few long-term studies that focus on cryotherapy as a treatment for prostate cancer.

The prostate gland surrounds the bottom of a man's bladder and about the first inch of the urinary tube, or urethra. It has a key role in male reproduction. The prostate gland secretes seminal fluid. That fluid combines with sperm to make semen.

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As a man ages, the prostate often becomes the target of several problems. One of these is prostate cancer. Each year, more than 200,000 men are diagnosed with prostate cancer. It is the most commonly diagnosed cancer in American men after non-melanomaskin cancer.

Even with early intervention and conventional treatment, 30% to 40% of men experience a recurrence of prostate cancer. That means they will need further treatment. Some experts think cryotherapy is an option for treating recurrent prostate cancer, especially if initial radiation therapy did not kill enough cancer cells.

How is cryotherapy done?

With cryotherapy, an ultra-thin metal probe or needle is inserted into the prostate gland. This is done through an incision that lies between the anus and scrotum. To protect the urethra from the procedure's icy temperatures, a warm saline solution flows through a catheter.

The surgeon uses visual information produced by ultrasound as a guide during the process. A freezing liquid, such as liquid nitrogen or more commonly, argon gas, is infused through the probe into the prostate gland. The intense cold freezes the prostate and destroys any cancerous tissue it contains. Using the images from the ultrasound to identify the cancer tissue, the surgeon can limit damage to normal prostate tissue.

How does cryotherapy destroy prostate cancer?

Any living tissue -- healthy or unhealthy -- cannot tolerate extreme cold. Infusing nitrogen or argon gas into the prostate gland rapidly extracts heat from the gland. As heat is drawn out, there is an instantaneous swell of ice crystals or ice balls. This results in the rupture of cell membranes. That's followed by tissue damage and, ultimately, cell death.

After the cancer cells are destroyed, white blood cells clean up the dead cells and tissue. Some studies show that during this process, the immune system strikes out and attacks cancer cells that still remain.

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