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    Antiphospholipid Syndrome

    Important
    It is possible that the main title of the report Antiphospholipid Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • antiphospholipid antibody syndrome
    • APLS
    • APS
    • Hughes syndrome
    • lupus anticoagulant syndrome
    • PAPS
    • primary antiphospholipid syndrome

    Disorder Subdivisions

    • CAPS
    • catastrophic antiphospholipid syndrome (Asherson's syndrome)

    General Discussion

    Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by recurring blood clots (thromboses). Blood clots can form in any blood vessel of the body. The specific symptoms and severity of APS vary greatly from case to case depending upon the exact location of a blood clot and the organ system affected. APS may occur as an isolated disorder (primary antiphospholipid syndrome) or may occur along with another autoimmune disorder such as systemic lupus erythematosus (secondary antiphospholipid syndrome).

    APS is characterized by the presence of antiphospholipid antibodies in the body. Antibodies are specialized proteins produced by the body's immune system to fight infection. In individuals with APS, certain antibodies mistakenly attack healthy tissue. In APS, antibodies mistakenly attack certain proteins that bind to phospholipids, which are fat molecules that are involved in the proper function of cell membranes. Phospholipids are found throughout the body. The reason these antibodies attack these proteins and the process by which they cause blood clots to form is not known.

    Resources

    Lupus Foundation of America, Inc.
    2000 L Street NW
    Suite 710
    Washington, DC 20036
    USA
    Tel: (202)349-1155
    Fax: (202)349-1156
    Tel: (800)558-0121
    Email: info@lupus.org
    Internet: http://www.lupus.org

    National Stroke Association
    9707 E. Easter Lane
    Suite B
    Centennial, CO 80112
    USA
    Tel: (303)649-9299
    Fax: (303)649-1328
    Tel: (800)787-6537
    Email: info@stroke.org
    Internet: http://www.stroke.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Autoimmune Information Network, Inc.
    PO Box 4121
    Brick, NJ 08723
    Fax: (732)543-7285
    Email: autoimmunehelp@aol.com

    APS Foundation of America
    PO Box 801
    La Crosse, WI 54602-0801
    Tel: (608)782-2626
    Fax: (608)782-6569
    Email: apsfa@apsfa.org
    Internet: http://www.apsfa.org

    National Blood Clot Alliance
    120 White Plains Road
    Suite 100
    Tarrytown, NY 10591
    Tel: (914)220-5040
    Tel: (877)466-2568
    Email: info@stoptheclot.org
    Internet: http://www.stoptheclot.org/index.htm

    Hughes Syndrome Foundation
    Conybeare House
    Guy's Hospital
    London, SE1 9RT
    United Kingdom
    Tel: 02071888217
    Email: info@hughes-syndrome.org
    Internet: http://www.hughes-syndrome.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 12/8/2011
    Copyright 1994, 1995, 1996, 2001, 2002, 2007, 2011 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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