Skip to content

    Vaccines Health Center

    Font Size
    A
    A
    A

    Sleep Helps Vaccines Work: Study

    Sleeping Less Than 6 Hours Nightly Linked to Lower Immune Response, Researchers Find
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    Aug. 1, 2012 -- People who regularly get more than seven hours of sleep a night are more likely to respond to vaccination against hepatitis B compared to those who get in less than six hours, according to new research.

    The differences were surprising, says researcher Aric Prather, PhD, a clinical health psychologist and Robert Wood Johnson Foundation Health & Society Scholar at the University of California, San Francisco, and the University of California, Berkeley.

    "People who slept less than six hours on average were 11.5 times more likely to be unprotected [after the vaccine] than those who slept more than seven hours," he says.

    He looked at the immune response to the hepatitis B vaccine in healthy adults.

    Hepatitis B, a serious infection that affects the liver, is the cause of death each year for about 2,000 to 4,000 in the U.S., according to the CDC.

    The study is published in Sleep.

    Sleep & Vaccines: Details

    Prather assessed 125 men and women, aged 40 to 60, who got the vaccine.

    He first tested them to be sure no one had been exposed to the hepatitis B virus.

    The hepatitis B vaccine includes two doses given a month apart. Those are followed by another dose at six months.

    The men and women wore a wrist device known as an actigraph to track sleep. Prather asked them to complete sleep diaries. He evaluated sleep duration, efficiency, and sleep quality.

    "We measured antibody response just before the second vaccine and just before the third, and then six months after the series was over," he says.

    By that time, a full response is expected.

    About 15% of those vaccinated did not achieve full protection six months after the series ended, he found.

    He looked at sleep habits and found a link. "What we found was, people who slept fewer hours on average produced fewer antibodies to the vaccine," Prather says.

    Prather stresses that he found a link, not cause and effect.

    However, he sees several ways in which sleep might affect antibody response. Sleep loss is linked to fluctuations in immune processes important to producing antibodies, for instance.

    It's too soon and too simple, Prather says, to tell people to get a good night's sleep before a vaccination.

    He found sleep habits over time, not just around the vaccine time, to be linked with a response.

    More research is needed, he says.

    Today on WebMD

    passport, pills and vaccine
    25 ways to protect yourself from illness.
    syringes and graph illustration
    Create a personalized schedule.
     
    flu shot signage
    Get answers to your questions
    gloved hand holding syringe
    Which ones do you need?
     
    woman walking
    Article
    Vaccine Schedule Are Your Childs Shots Up To Date
    Article
     
    69x75 thumbnail early pregnancy 02
    VIDEO
    gloved hand holding syringe
    Article
     
    adult vaccine injection
    ARTICLE
    woman peeking under sheets
    Tool
     
    cold season and vitamin C
    VIDEO
    Adult Meningitis Vaccines What You Should Know
    ARTICLE