How Do I Know If I have Lyme Disease?

Lyme disease can be tricky to diagnose. The signs and symptoms can look like many other health problems. The ticks that spread it can pass other diseases on to you at the same time. Plus, the tests that check for it aren’t exact. Because of this, you could be told you have Lyme disease when you don’t.

What Is Lyme Disease?

This bacterial infection is spread through the bite of a young deer tick or black-legged tick. These eight-legged creatures, about the size of a poppy seed, can be found in wooded and grassy areas throughout the United States, especially in New England and the Rocky Mountains.

Because these ticks are so small, most people don’t realize when they’re bitten. But the longer a tick stays attached to you, the more likely it is to transmit Borrelia burgdorferi (the bacteria that causes Lyme disease), if the tick is a carrier.

If not found and treated, Lyme disease can lead to problems with your joints, heart, and nervous system. It can even affect your memory.

How Is It Diagnosed?

If you’ve been outside in an area where ticks are known to live, you should tell your doctor. She’ll also want to know about the symptoms you’re having. These details are crucial to making a diagnosis of Lyme disease.

Symptoms can include:

  • Fever
  • Rash that may look like a “bull’s-eye”
  • Headaches
  • Stiff neck
  • Facial palsy (Drooping or loss of muscle tone in your face)
  • Severe joint pain or swelling
  • Dizziness
  • Shortness of breath
  • Tingling in the hands and feet
  • Bone pain
  • Racing heart
  • Problems with your short-term memory

Symptoms that come and go are common with Lyme disease. They will also depend on the stage of the disease.

Is There a Blood Test for Lyme Disease?

If your doctor suspects that you have Lyme disease, she may order two blood tests. These will look for signs that your body is trying to fight it off. The results are most precise a few weeks after you’ve been infected.

These tests are:

ELISA (enzyme-linked immunosorbent assay) test. This test can’t check for the bacteria that causes Lyme disease. It can only look for your immune system’s response to it.


Once Borrelia burgdorferi gets into your blood, your body begins to make special proteins called antibodies to fight it off. The ELISA test checks for those antibodies.

Although it’s the most common way to check for Lyme disease, the ELISA test isn’t perfect. It can sometimes give false “positive” results. On the other hand, if you have it done too soon after you’ve been infected, your body may not have developed enough antibodies for the test to detect them. This will give you a “negative” result even though you do have Lyme disease.

Western blot test. Whether your ELISA test comes back positive or negative, your doctor will need to do this blood test, too.

A Western blot uses electricity to split certain proteins in your blood into patterns. This is then compared to the pattern of people known to have Lyme disease.

At least five band matches means that you have Lyme disease. Still, not all labs have the same standards. There’s a chance that you could get a “positive” result from one and a “negative” result from another.

Also, Some labs offer a test for Lyme disease using your pee or other body fluids. These methods aren’t approved by the FDA. Studies also show that the results often aren’t correct. You may be told that you have Lyme disease when you don’t.

Other tests: Lyme disease is called “The Great Imitator” because it mimics so many different health conditions. Your doctor may also want to do more blood or imaging tests to rule out:

What Else Should I Know?

If you think you have Lyme disease, it’s a good idea to see a board-certified infectious disease specialist. This type of doctor is skilled in both diagnosis and treatment.

The tests that look for Lyme disease aren’t foolproof, so your doctor may decide to start you on treatment based on your symptoms and the likelihood you’ve been exposed to ticks.

WebMD Medical Reference Reviewed by David Zelman, MD on March 31, 2017



Mayo Clinic: “Lyme Disease.” “About Lyme Disease,” “Lyme Disease Diagnosis.”

Lyme Research Alliance: “Diagnostic Dilemma: A Guide: The Diagnostic Dilemma of Lyme Disease.”

CDC: “Lyme Disease: Diagnosis and Testing,” “Signs and Symptoms of Untreated Lyme Disease,” “Lyme Disease: Two-Step Laboratory Testing Process.”

National Institute of Allergy and Infectious Diseases: “Lyme Disease Diagnostics Research.”

American Lyme Disease Foundation: “How To Find a Physician To Treat Lyme Disease.”

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