This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
These antibiotics may prevent each other from working.
What might happen:
Your antibiotics may not work as well against your infection.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to change one or both of your antibiotics.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Igarashi K, Ishitsuka H, Kaji A. Comparative studies on the mechanism of action of lincomycin, streptomycin, and erythromycin. Biochem Biophys Res Commun 1969 Oct 22;37(3):499-504.
- 2.Weinstein L. Modes of action of antibiotics on bacteria and man. N Y State J Med 1972 Sep 1;72(17):2166-70.
- 3.Garrett ER, Heman-Ackah SM, Perry GL. Kinetics and mechanisms of action of drugs on microorganisms. XI. Effect of erythromycin and its supposed antagonism with lincomycin on the microbial growth of Escherichia coli. J Pharm Sci 1970 Oct;59(10):1448-56.
- 4.Mao JC. The stoichiometry of erythromycin binding to ribosomal particles of Staphylococcus aureus. Biochem Pharmacol 1967 Dec;16(12):2441-3.
- 5.Cleocin (clindamycin hydrochloride) US prescribing information. Pharmacia and Upjohn Company March, 2018.
- 6.Lincocin (lincomycin) US prescribing information. Pharmacia and Upjohn June, 2007.
- 7.Dinos GP, Michelinaki M, Kalpaxis DL. Insights into the mechanism of azithromycin interaction with an Escherichia coli functional ribosomal complex. Mol Pharmacol 2001 Jun;59(6):1441-5.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.