Selected Benzodiazepines/Phenobarbital; Primidone Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your medicine may speed up how quickly your liver processes your benzodiazepine.Phenobarbital and a benzodiazepine, especially when you first start them, may cause sedation or suppress your natural urge to breathe.

What might happen:

Over time, your benzodiazepine might not work as well.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have stopped taking your other medicine in the previous two weeks. Let your doctor know if your benzodiazepine does not seem to be working as well, or if you might be having side effects such as sedation, confusion, feeling dizzy or uncoordinated. Your doctor may need to adjust the dose of your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.