Dacarbazine Vial

COMMON BRAND(S): DTIC-Dome

GENERIC NAME(S): Dacarbazine

OTHER NAME(S): Dacarbazine Solution, Reconstituted (Recon Soln)

WARNINGS:

This medication may often cause serious blood disorders (decreased bone marrow function leading to a low number of red blood cells, white blood cells, and platelets). These effects can cause anemia, lower your body's ability to fight an infection, and increase your risk of bleeding. Dacarbazine may also cause rare but serious liver problems. These side effects may rarely be life-threatening. Your doctor will monitor you closely while you are receiving this medication.

Tell your doctor right away if you develop any of the following symptoms: unusual tiredness, pale skin, easy bruising/bleeding, signs of infection (e.g., fever, chills, persistent sore throat), persistent nausea/vomiting, dark urine, yellowing eyes/skin, stomach/abdominal pain.

Who should not take Dacarbazine Vial?

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Uses

Uses

Dacarbazine is used to treat certain types of cancer, such as skin cancer that has spread (metastatic malignant melanoma) and Hodgkin's disease. It is a cancer chemotherapy drug that is used alone or with other medications to slow or stop cancer cell growth.

How to use Dacarbazine Vial

This medication is given by injection into a vein by a health care professional. It is given on a schedule as directed by your doctor. Dosage is based on your medical condition, body size, and response to treatment.

Side Effects

Side Effects

See also Warning section.

Nausea, vomiting, and loss of appetite commonly occur. Vomiting may last up to 12 hours. Your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating for 4 to 6 hours before treatment, or limiting activity may help lessen these effects. These symptoms usually decrease after 1 to 2 days. Diarrhea, flu-like symptoms (e.g., discomfort, uneasiness, body aches, headache), blurred vision, or flushing/numbness/tingling of the face may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk ofside effects. Careful monitoring by your doctor may decrease your risk.

If this medication leaks out of the vein into the tissue under the skin, it may cause serious tissue damage. Tell your doctor right away if you experience pain, burning, redness, or swelling at the injection site.

Tell your doctor right away if you have any serious side effects, including: mouth sores, confusion, seizures.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Precautions

Before using dacarbazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, blood disorders, decreased bone marrow function, current infections.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received polio vaccine by mouth or flu vaccine inhaled through the nose.

Since this medication can increase your risk of developing serious infections, wash your hands well to prevent the spread of infections. Avoid contact with people who have illnesses that may spread to others (e.g., flu, chickenpox).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like safety razors and nail cutters, and avoid activities such as contact sports.

This drug may rarely cause blurred vision. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Due to the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

This medication can affect sperm production in men. Therefore, reliable forms of birth control should be used during treatment and for some time afterwards. Consult your doctor for more details.

Interactions

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: drugs that may decrease bone marrow function (e.g., azathioprine, trimethoprim/sulfamethoxazole).

Overdose

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Laboratory and/or medical tests (e.g., complete blood counts) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule.

Storage

Not applicable. This medication is given in a clinic and will not be stored at home.Information last revised November 2016. Copyright(c) 2016 First Databank, Inc.

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dacarbazine 200 mg intravenous solution
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dacarbazine 200 mg intravenous solution

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dacarbazine 100 mg intravenous solution
dacarbazine 100 mg intravenous solutioniconicon
dacarbazine 100 mg intravenous solution

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dacarbazine 200 mg intravenous solution
dacarbazine 200 mg intravenous solutioniconicon
dacarbazine 200 mg intravenous solution

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dacarbazine 200 mg intravenous solution
dacarbazine 200 mg intravenous solutioniconicon
dacarbazine 200 mg intravenous solution

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dacarbazine 200 mg intravenous solution
dacarbazine 200 mg intravenous solution

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colorless
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No data.
This medicine is a colorless, vial
dacarbazine 200 mg intravenous solution
dacarbazine 200 mg intravenous solution

color
colorless
shape
No data.
imprint
No data.
This medicine is a colorless, vial
dacarbazine 100 mg intravenous solution
dacarbazine 100 mg intravenous solution

color
white
shape
No data.
imprint
No data.
This medicine is a white, vial
dacarbazine 200 mg intravenous solution
dacarbazine 200 mg intravenous solution

color
white
shape
No data.
imprint
No data.
This medicine is a white, vial
dacarbazine 200 mg intravenous solution
dacarbazine 200 mg intravenous solution

color
colorless
shape
No data.
imprint
No data.
This medicine is a colorless, vial

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.