Laboratory and/or medical tests (such as blood pressure, urine protein, complete blood count, liver/thyroid function) should be performed regularly to monitor your progress or check for side effects. Consult your doctor for more details.
How to use Ramucirumab Solution
This medication is given by slow injection (usually over 30 minutes or 60 minutes) into a vein by a health care professional. It is given as directed by your doctor, usually every 2 weeks or every 3 weeks.
Infusion reactions may happen while you are receiving ramucirumab. To prevent these side effects, your doctor will also prescribe medications (such as antihistamines, acetaminophen) for you to receive before each injection. Carefully follow your doctor's instructions. Tell your doctor right away if you have any symptoms of infusion reactions such as shaking, back pain/spasms, chest tightness, chills, flushing, rapid heartbeat, dizziness, or skin tingling/burning.
The dosage is based on your medical condition, weight, and response to treatment.
You should receive this medication regularly to get the most benefit from it. To help you remember, mark your calendar to keep track of when to receive the next dose.
See also How to Use section.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine, swelling hands/ankles/feet), redness/blisters/swelling/pain on the palms of your hands or soles of your feet, slow wound healing.
Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, trouble speaking, confusion, sudden vision changes, seizure, sudden/severe back pain or headache.
This medication may cause serious (possibly fatal) bleeding. It may also rarely cause a hole to open in the stomach or intestines (gastrointestinal perforation). Tell your doctor right away if you have symptoms such as stomach/abdominal pain that doesn't go away, easy bleeding/bruising, bloody or black/tarry stools, vomit that looks like coffee grounds, coughing up blood, lightheadedness, unusual tiredness/weakness.
This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent sore throat, cough).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before receiving ramucirumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, kidney disease, liver disease, recent surgery, recent injuries/wounds, bleeding/blood problems (such as bleeding of the stomach/intestines), blood vessel problems (such as an aneurysm or a tear/break in the aorta or other blood vessels).
Ramucirumab can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.
To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.
This medication may cause wounds to heal slowly or poorly. Before having surgery, talk with your doctor about the risks and benefits of this medication. Your doctor may tell you to temporarily stop treatment with this medication at least 28 days before surgery. Ask your doctor for specific instructions about when to stop and when to restart treatment with ramucirumab. Tell your doctor right away if you have wounds that are not healing well.
This medication may decrease fertility in women of childbearing age. Ask your doctor for details.
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using ramucirumab. Ramucirumab may harm an unborn baby. Your doctor should order a pregnancy test before you start this medication. Ask about reliable forms of birth control while using this medication and for 3 months after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using this drug and for 2 months after stopping treatment. Consult your doctor before breast-feeding.
Consult your pharmacist or physician.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Not applicable. This medication is given in a hospital or clinic and will not be stored at home.