Ramucirumab Solution

GENERIC NAME(S): Ramucirumab

WARNINGS:

This medication may cause serious (possibly fatal) bleeding. It may also rarely cause a hole to open in the stomach or intestines (gastrointestinal perforation). You should not receive this medication if you have any serious bleeding problems. Tell your doctor right away if you have symptoms of serious side effects, including prolonged bleeding from cuts or gums, persistent/frequent nosebleeds, pink/dark urine, unusual/easy bruising, bloody or black/tarry stools, persistent or severe stomach/abdominal pain, vomit that looks like coffee grounds, coughing up blood, shortness of breath, dizziness/fainting, unusual or persistent tiredness/weakness, severe headache.

Who should not take Ramucirumab Solution?

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Uses

Uses

Ramucirumab is used to treat various types of cancers. It works by slowing or stopping the growth of cancer cells.

How to use Ramucirumab Solution

This medication is given by slow injection (usually over 60 minutes) into a vein by a health care professional. It is given as directed by your doctor, usually every 2 weeks to treat stomach, colon, or rectal cancer and every 3 weeks to treat lung cancer. To decrease the risk of injection side effects, you doctor will also prescribe medications (such as antihistamines, acetaminophen) for you to receive before each injection. Carefully follow your doctor's instructions.

The dosage is based on your medical condition, weight, and response to treatment.

You should receive this medication regularly to get the most benefit from it. To help you remember, mark your calendar to keep track of when to receive the next dose.

Side Effects

Side Effects

See also Warning section.

Diarrhea, headache, nausea, vomiting, mouth sores, or weakness may occur. Injection reactions such as shaking, back pain/spasms, chest tightness, chills, flushing, rapid heartbeat, dizziness, or skin tingling/burning may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine, swelling hands/ankles/feet), redness/blisters/swelling/pain on the palms of your hands or soles of your feet.

Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, slurred speech, confusion, sudden vision changes, seizure.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your blood pressure with medication.

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent sore throat, cough).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Precautions

See also Warning section.

Before receiving ramucirumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, kidney disease, liver disease, recent surgery, recent injuries/wounds, bleeding/blood problems (such as bleeding of the stomach/intestines).

Ramucirumab can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Before having surgery or any medical procedure, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may cause wounds to heal slowly or poorly. Before having surgery, talk with your doctor about the risks and benefits of this medication. Your doctor may tell you to temporarily stop treatment with this medication before surgery. Ask your doctor for specific instructions about when to stop and when to restart treatment with ramucirumab. Tell your doctor right away if you have wounds that are not healing well.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits, and ask your doctor which reliable forms of birth control to use during and for 3 months after stopping treatment. If you become pregnant or think you may be pregnant, tell your doctor right away.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication.

It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

InteractionsOverdose

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Laboratory and/or medical tests (such as blood pressure, urine protein, complete blood count, liver/thyroid function) should be performed regularly to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule.

Storage

Not applicable. This medication is given in a hospital or clinic and will not be stored at home.Information last revised January 2019. Copyright(c) 2019 First Databank, Inc.

Images

Sorry. No images are available for this medication.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.