Who should not take XIGDUO XR?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • an infection
  • low blood sugar
  • pituitary hormone deficiency
  • decreased function of the adrenal gland
  • inadequate vitamin B12
  • excess body acid
  • dehydration
  • alcoholism
  • alcohol intoxication
  • a heart attack
  • sudden and serious symptoms of heart failure called acute decompensated heart failure
  • liver problems
  • fever
  • a condition where the body is unable to maintain adequate blood flow called shock
  • excessive vomiting
  • excessive diarrhea
  • serious lack of oxygen in the blood
  • weakened patient
  • sepsis
  • chronic kidney disease stage 3B (moderate)
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • kidney disease with likely reduction in kidney function
  • high cholesterol
  • method of removing waste/poison from blood with dialysis
  • pregnancy
  • decreased blood volume
  • chronic kidney disease stage 3B (moderate)
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • necrotizing fasciitis, a condition where deep tissues die in the area of the genitals to the anus

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.