How to use Isavuconazonium Sulfate Solution, Reconstituted (Recon Soln)
This medication is given by injection into a vein as directed by your doctor, usually every 8 hours for the first 6 doses (48 hours). Then 12 to 24 hours after the first 6 doses, it will be given once daily. This medication should be injected slowly over 1 hour. In children, the dosage is based on weight.
If you are using this medication at home, learn all preparation and usage instructions from your health care professional. You should use an in-line filter with this medication. It is normal for this product to have white particles in the liquid. Before using, check this product visually for other particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
If you are giving this medication through a nasogastric tube, ask your health care professional for detailed instructions on how to properly mix and give it.
This medication works best when the amount of medicine in your body is kept at a constant level. Use this drug at evenly spaced intervals.
Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
Tell your doctor if your condition does not improve or if it worsens.
Nausea, vomiting, diarrhea, headache, constipation, cough, and trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Symptoms of an infusion reaction that may occur during isavuconazonium treatment include dizziness, fainting, trouble breathing, chills, numb/tingling skin, changes in your sense of touch. Your doctor will monitor you closely and will stop your treatment if a reaction occurs.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: muscle cramps/spasms, weakness, irregular heartbeat, swelling hands/ankles/feet, back pain, mental/mood changes (such as confusion, anxiety).
Get medical help right away if you have any very serious side effects, including: fast/irregular/pounding heartbeat, chest pain, fainting, signs of kidney problems (such as change in the amount of urine), seizures.
Isavuconazonium may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.
Isavuconazonium can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Tell your doctor right away if you develop any rash.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using isavuconazonium, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, family history of certain heart problems (short QT syndrome, abnormal heart rate/rhythm).
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using isavuconazonium. Isavuconazonium may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for 28 days after the last dose. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include asunaprevir, bosutinib, elacestrant, flibanserin, lomitapide, lonafarnib, tolvaptan, among others.
Other medications can affect the removal of isavuconazonium from your body, which may affect how isavuconazonium works. Examples include adagrasib, certain azole antifungals (such as itraconazole, ketoconazole), certain HIV protease inhibitors (such as nelfinavir, saquinavir), nefazodone, certain rifamycins (such as rifabutin, rifampin), ritonavir, certain drugs used to treat seizures (such as carbamazepine, phenobarbital), St. John's wort, among others.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.