Elbasvir-Grazoprevir/OATP1B1-3 Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your other medicine may speed up how quickly your body processes elbasvir-grazoprevir.

What might happen:

Your elbasvir-grazoprevir may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want check how your elbasvir-grazoprevir is working or the amount of elbasvir-grazoprevir in your blood. Your doctor may want to change your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Zepatier (elbasvir-grazoprevir) US prescribing information. Merck & Co., Inc. June, 2018.
  • 2.Zepatier (elbasvir-grazoprevir) Canadian product monograph. Merck Canada Inc. January 19, 2016.
  • 3.Prezista (darunavir) US prescribing information. Tibotec Inc. September, 2018.
  • 4.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company March, 2018.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.