What should I Know Regarding Pregnancy, Nursing and Administering XELJANZ XR to Children or the Elderly?

If you are pregnant

  • Not Recommended:
  • If you are nursing

  • If you are an adult over 60

  • management or monitoring precaution: General-Weigh risk-benefit. Serious infection rates higher in the elderly. Monitor closely. Increased thromboembolic risk and cancer risk in patient age > 50 years. (FDA Medwatch) Cardiovascular-Increased risk of MI in patient age > 50 years. DVT/PE risk increased with heart failure per European Medicines Agency and FDA Medwatch Renal-Reduce dose to 5 mg once daily for moderate-severe renal impairment. Hepatic-Reduce dose to 5 mg once daily for moderate hepatic impairment.
  • Pediatric use

  • Severe Precaution: Safety and efficacy not established in age < 2 years.
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.