Ravulizumab-cwvz can lower your body's ability to fight infections. This increases your chance of getting very serious (possibly fatal) infections (especially meningitis or sepsis). Get medical help right away if you develop symptoms such as nausea/vomiting that doesn't stop, high fever, chills, severe headache, stiff neck, mental/mood changes (such as confusion), eye sensitivity to light.

You should receive the vaccine for meningitis (meningococcal vaccine) at least 2 weeks before receiving this medication. If you have been vaccinated for meningitis in the past, ask your doctor if you should get another vaccination (booster shot) before receiving this medication. Vaccines may not fully protect everyone who receives them, so you should still watch for signs of meningitis after you get the vaccine.

For patients to receive this medication, all doctors, pharmacists, and patients must agree to, understand, and carefully follow the requirements of the Ultomiris REMS Program. These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.


Ravulizumab-cwvz is used to treat a certain blood disorder (paroxysmal nocturnal hemoglobinuria). This disorder causes your body's immune system to destroy red blood cells, which results in anemia. It works by helping block your body's destruction of red blood cells. This effect helps lessen symptoms of anemia (such as tiredness, shortness of breath), and may reduce the need for blood transfusions. This medication may also be used to treat a certain immune system disorder (atypical Hemolytic Uremic Syndrome). It helps to prevent blood clots caused by this disorder. Ravulizumab-cwvz belongs to a class of medications known as monoclonal antibodies.

How to use Ravulizumab-Cwvz Solution

Read the Medication Guide provided by your pharmacist. Carry the Patient Safety Card with you at all times during treatment and for 8 months after your last dose of ravulizumab-cwvz. If you have any questions, ask your doctor or pharmacist.

This medication is given by slow injection into a vein by a health care professional as directed by your doctor. After the first dose, it is usually given 2 weeks later, then every 4 to 8 weeks. The dosage is based on your medical condition, weight, and response to treatment.

Reactions may happen with your injection. To monitor you and decrease your risk of a serious reaction, you should remain in the hospital or clinic for at least 1 hour after your injection. Tell your health care professional right away if you have symptoms such as low back pain, pain with the injection, chest pain, shortness of breath, or feeling faint.

Do not stop using this medication without consulting your doctor. Your condition may become worse when the drug is stopped. If you do stop using this medication, your doctor will monitor you for at least 16 weeks to make sure your condition does not get worse. Consult your doctor for more details.

Tell your doctor if your condition does not get better or if it gets worse.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.