Uses
What is Xcopri used for?
Xcopri is commonly used for partial-onset seizures, also known as focal seizures.
Learn more about How Xcopri Works for Partial-Onset Seizures.
Xcopri may also be used for other conditions as determined by your healthcare provider.
How does Xcopri work (mechanism of action)?
Xcopri lowers brain stimulation by decreasing the amount of signals that certain cells in the brain send.
How is Xcopri supplied (dosage forms)?
Xcopri is available in the following dosage forms that are taken by mouth.
- 12.5 mg oral tablets
- 25 mg oral tablets
- 50 mg oral tablets
- 100 mg oral tablets
- 150 mg oral tablets
- 200 mg oral tablets
How should I store Xcopri?
Xcopri should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Keep Xcopri in a safe place.
Side Effects
What are the most common side effects of Xcopri?
The most common side effects of Xcopri are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Drowsiness (or sleepiness)
- Dizziness
- Tiredness
- Double vision
- Headache
There may be other side effects of Xcopri that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Xcopri?
While less common, the most serious side effects of Xcopri are described below, along with what to do if they happen.
Severe Allergic Reactions. Xcopri may cause allergic reactions, including a specific type of allergic reaction called DRESS. DRESS stands for Drug Reaction with Eosinophilia and Systemic Symptoms. It is also sometimes called multiorgan hypersensitivity. This is a reaction that can affect multiple parts of the body, including your liver, kidneys, and heart. Stop taking the medicine and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
- Dark-colored pee
- Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
Heart Rhythm Changes. Xcopri may cause a rare, dangerous heart rhythm problem called QT shortening. Tell your healthcare provider right away if you faint or have changes in your heart rate or rhythm, such as a fast or skipping heartbeat.
Suicidal Thoughts and Actions. Xcopri may cause suicidal thoughts or actions in a small number of people. If you are about to harm yourself, call 911 or call or text 988, the Suicide & Crisis Lifeline. Call your healthcare provider right away if you have any of the following symptoms.
- New or increased thoughts of suicide or death
- Suicide attempt
- New or increased feelings of anxiety, depression, or other unusual changes in mood or behavior including feeling agitated, restless, or irritated, having panic attacks, acting aggressive or being angry or violent, acting on dangerous impulses, or mania
- Trouble sleeping
Nervous System Problems. Xcopri may cause problems with your nervous system. Tell your healthcare provider right away if you have any of the following symptoms.
- Dizziness
- Trouble walking or loss of coordination
- Feeling sleepy or tired
- Trouble concentrating, remembering, or thinking clearly
- Vision problems including double vision or blurry vision
Withdrawal Reaction. If you stop Xcopri suddenly, it could lead to increased seizures and increase your risk of having status epilepticus, which is a seizure that lasts more than 5 minutes. Do not stop taking Xcopri without talking with your healthcare provider. Your healthcare provider will tell you how to stop Xcopri to reduce the risk of withdrawal reactions. Call your healthcare provider right away or go to the nearest emergency room if you or your loved one experience a seizure that lasts more than 5 minutes.
Warnings & Precautions
Who should not use Xcopri?
Allergies to Ingredients. People who are allergic to any of the following should not take Xcopri.
- Xcopri
- Cenobamate
- Any of the ingredients in the specific product dispensed
Familial Short QT syndrome. People who have a condition called Familial Short QT syndrome, which is a rare genetic condition that causes heart rhythm problems, should not take Xcopri. People who have Familial Short QT syndrome and take Xcopri may be at a higher risk of developing heart rhythm problems and an increased risk of sudden death.
What should I know about Xcopri before using it?
Xcopri is a Schedule V controlled substance, meaning the medicine can potentially be abused or can lead to dependence, in which your body starts to rely on the medicine.
Xcopri can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how Xcopri affects you.
When you first start taking Xcopri, your healthcare provider will slowly increase your dose around every 2 weeks.
Xcopri is taken once a day, by mouth, at any time of the day, with or without food.
Xcopri can also be crushed and mixed with water to take by mouth or by nasogastric (NG) tube. Talk to your healthcare provider about how to prepare the water/medicine mixture.
Do not take Xcopri unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share Xcopri with other people, even if they have the same condition as you. It may harm them. Selling or giving away Xcopri is against the law.
Keep Xcopri out of the reach of children. Xcopri is a controlled substance because it can be misused or lead to dependence. Store Xcopri in a safe place to protect it from theft. It is illegal to sell or give away this medicine.
What should I tell my healthcare provider before using Xcopri?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Xcopri is right for you.
In particular, make sure that you discuss any of the following.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
- Currently have, or have had a history of depression, mood problems, suicidal thoughts, or suicidal actions.
- Have had liver, kidney, or blood problems
- Have had an allergic reaction to a medicine that has caused a rash or has affected the organs in your body
Other Medicines and Supplements. Xcopri may interact with other medicines and supplements. Before using Xcopri, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. It is not known if or how Xcopri could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take Xcopri while you are pregnant or trying to get pregnant. If you become pregnant while taking Xcopri you can register for the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling 888-233-2334 or at www.aedpregnancyregistry.org. This registry collects safety information about the use of antiepileptic medicines during pregnancy.
Breastfeeding. It is not known if Xcorpi passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take Xcopri while breastfeeding.
How can I get more information about Xcopri?
For more information about Xcopri, you can visit the manufacturer’s website at www.xcopri.com or call them at 866-657-5574.
Interactions
Does Xcopri interact with foods or drinks?
Do not drink alcohol while taking Xcopri without talking to your healthcare provider. The risk of drowsiness or sleepiness may be increased if you drink alcohol while taking Xcopri.
Does Xcopri interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before taking Xcopri
- Phenytoin (Dilantin, Phenytek, and others) or clobazam (Onfi), which are medicines to control seizures
- Phenobarbital, which is a medicine that may be used to treat insomnia or seizures
- Lamotrigine (Lamictal) or carbamazepine (Tegretol, Carbatrol), which are medicines used to control seizures or manage bipolar disorder.
- A birth control pill
- Medicines that make you sleepy or dizzy
- Medicines that affect your heart rhythm
Xcopri may alter the blood levels of some other medicines. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Xcopri. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Xcopri?
If you or someone else has used too much Xcopri, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Xcopri?
Talk to your healthcare provider about what you should do if you miss a dose of Xcorpi.