Tucatinib 150 Mg Tablet

GENERIC NAME(S): Tucatinib

OTHER NAME(S): Tucatinib Tablet

Uses

Uses

This medication is used to treat breast cancer. Tucatinib belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells.

How to use Tucatinib 150 Mg Tablet

Read the Patient Information Leaflet if available from your pharmacist before you start taking tucatinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually twice daily (about 12 hours apart). Swallow the medication whole. Do not chew, crush, or split the tablets. Do not take tablets if they are broken, cracked, or damaged.

If you miss a dose or vomit after taking tucatinib, do not take another dose. Take your next dose at the regular time.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Side Effects

Side Effects

Nausea, vomiting, mouth sores/pain, loss of appetite, weight loss, tiredness, or muscle/joint pain may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Diarrhea is a common side effect and can sometimes be severe. Vomiting/diarrhea that doesn't stop may result in a serious loss of body water (dehydration). Contact your doctor promptly if you notice any symptoms of dehydration, such as unusual decreased urination, unusual dry mouth/thirst, fast heartbeat, or dizziness/lightheadedness. Your doctor may prescribe anti-diarrheal medication to take during treatment with this medication.

People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Tucatinib may make you develop a skin problem called hand-foot syndrome. To help prevent this, protect your hands and feet from heat or increased pressure. Avoid activities such as using hot dishwater, taking tub baths, jogging, going on long walks, or using garden or household tools such as screwdrivers. Symptoms may include pain, swelling, redness, blisters, or numbness of the hands/feet. Your doctor may prescribe medication (such as balm) to help with symptoms. If symptoms affect your usual activities, get medical help right away.

Tucatinib may rarely cause serious (possibly fatal) liver disease. Your doctor should check liver function tests before you start taking this medication and every 3 weeks during treatment, or as needed. Get medical help right away if you have any symptoms of liver damage, such as: nausea/vomiting that doesn't stop, stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Precautions

Before taking tucatinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver problems.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Tell your doctor if you are pregnant or plan to become pregnant. Women of childbearing age should have a pregnancy test before starting treatment. You should not become pregnant while using tucatinib. Tucatinib may harm an unborn baby. Men with female partners of childbearing age should ask about reliable forms of birth control while using this medication and for at least 1 week after the last dose. Women of childbearing age should ask about reliable forms of birth control while using this medication and for at least 1 week after the last dose. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for at least 1 week after the last dose is not recommended. Consult your doctor before breast-feeding.

Interactions

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications can affect the removal of tucatinib from your body, which may affect how tucatinib works. Examples include rifamycins (such as rifabutin, rifampin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include avanafil, some benzodiazepines (such as midazolam, triazolam), ergot drugs (such as ergotamine, dihydroergotamine), some "statin" drugs (such as lovastatin, simvastatin), ubrogepant, among others.

Overdose

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, kidney/liver function) should be done before you start taking this medication and while you are taking it. Keep all medical and lab appointments.

Missed Dose

If you miss a dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store tightly closed in the original container at room temperature away from light and moisture. Do not store in the bathroom. Keep the desiccant (drying agent) in the bottle. After opening the bottle, use/discard within 3 months. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised April 2020. Copyright(c) 2020 First Databank, Inc.

Images

Sorry. No images are available for this medication.

Drug Survey

Are you taking Tucatinib 150 Mg Tablet?

Are you considering switching to Tucatinib 150 Mg Tablet?

How satisfied are you with the results?

VERY POOR
POOR
FAIR
GOOD
EXCELLENT

Are you planning to see a doctor about switching your medication?

How long have you been taking Tucatinib 150 Mg Tablet?

Are you planning to see a doctor about switching your medication?

Thanks for taking our survey!

Recommended For You

Find a doctor near you

More Resources for Tucatinib 150 Mg Tablet

Free Rx Coupon

Save up to 80% on your prescriptions.

Find More Drugs Used to Treat these Conditions

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.