Uses

Apomorphine is used to treat "off" episodes in people with Parkinson's disease. It can improve your ability to move during these "off" periods. Apomorphine is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.

How to use

Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using apomorphine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Use this medication as directed by your doctor. Drink some water to moisten your mouth before use. This helps the film dissolve. Use only whole films. Do not cut or chew the film or use a film that is broken or missing pieces. With dry hands, open the foil packet just before use and place the medication film under your tongue and then close your mouth. Keep the film in place until it completely dissolves (usually about 3 minutes). Do not talk, swallow, chew, or move the film while it is dissolving or it will not work as well.

The dosage is based on your medical condition and response to treatment. Doses of this medication should be separated by at least 2 hours, with no more than 5 doses per day. No more than 1 dose should be taken for each "off" episode. Follow your doctor's instructions carefully.

To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Your first dose may be at a doctor's office where you can be monitored for side effects. Nausea is very common with this medication. To decrease the risk of nausea, your doctor may direct you to start taking another medication (such as trimethobenzamide) 3 days before your first dose of apomorphine and to continue taking as directed for up to 2 months.

If you are using this medication frequently and suddenly stop using it, you may have withdrawal symptoms (such as anxiety, depression, confusion, fever, muscle stiffness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used apomorphine for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Rarely, abnormal drug-seeking behavior (drug abuse) is possible with this medication. Do not increase your dose or use it more frequently than prescribed. Properly stop the medication when so directed.

Tell your doctor if your condition does not get better or if it gets worse.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.