Uses
What is Twyneo used for?
Twyneo is commonly used to treat acne vulgaris. Acne vulgaris is a common type of acne that causes blackheads, whiteheads, and other types of pimples on your skin. It often appears on the face, chest, shoulders, and back.
Twyneo may also be used for other conditions as determined by your healthcare provider.
How does Twyneo work (mechanism of action)?
Twyneo, which is applied to the affected skin, has two ingredients: tretinoin and benzoyl peroxide. Tretinoin helps clear acne by making your skin shed old cells faster and preventing clogged pores. Benzoyl peroxide kills bacteria (germs) and helps remove dead skin cells to keep your pores clear.
How is Twyneo supplied (dosage forms)?
Twyneo (tretinoin/benzoyl peroxide) is available as a 0.1%/3% topical cream that is applied to the skin.
How should I store Twyneo?
Twyneo should be stored at room temperature, between 68 F to 77 F (20 C to 25 C), for up to 12 weeks after you get it from the pharmacy, or 60 days after you open it (whichever comes first). Store in a cool, dry place.
Side Effects
What are the most common side effects of Twyneo?
The most common side effects of Twyneo are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Skin reactions (see below)
There may be other side effects of Twyneo that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Twyneo?
While less common, the most serious side effects of Twyneo are described below, along with what to do if they happen.
Severe Allergic Reactions. Twyneo may cause allergic reactions, which can be serious. Stop using Twyneo and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Skin Reactions. Twyneo can cause skin irritation. Contact your healthcare provider if you have any of the following symptoms that bother you or do not go away. Your healthcare provider may advise you to use moisturizer, use the medicine less often, or stop using the medicine.
- Skin redness
- Dry skin
- Flaking or peeling skin
- Skin burning, stinging, or pain
Sensitivity to Sunlight. Your skin may be very sensitive to light from the sun and devices that give off similar light, such as sunlamps and tanning beds, while you are taking certain drugs, including Twyneo. This is called photosensitivity. Limit or avoid your time in natural or artificial sunlight while using Twyneo. Use sunscreen and wear a hat and clothes that cover your skin if you need to be in the sunlight. Exposing your skin to this kind of light, even for a short time, can cause your skin to be severely sunburned, blistered, or swollen. Tell your healthcare provider right away if any of these happen. Stop using Twyneo right away if you get a sunburn.
Warnings & Precautions
Who should not use Twyneo?
Allergies to Ingredients. People who are allergic to any of the following should not use Twyneo.
- Tretinoin
- Benzoyl peroxide
- Twyneo
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Twyneo.
What should I know about Twyneo before using it?
Do not use Twyneo unless it has been prescribed to you by a healthcare provider. Use it as prescribed.
Twyneo is only applied to your skin. Do not use the medicine in or on the eyes, mouth/lips, corners of the nose, or vagina.
Do not share Twyneo with other people, even if they have the same condition as you. It may harm them.
Keep Twyneo out of the reach of children.
If possible, stay out of direct sunlight and sunlamps while using Twyneo. If you are often in the sun or have sensitive skin, be extra careful. Use sunscreen and wear a hat if you cannot avoid the sun.
Do not use Twyneo on cuts, scrapes, sunburned skin, or skin affected by eczema (a condition that causes red, itchy, and inflamed skin).
Before applying Twyneo, gently wash the skin, rinse with warm water, and pat it dry. Wash your hands right away after using this medicine.
Twyneo may bleach (remove color from) your clothes or hair. Do not get the medicine on colored fabric or hair.
Throw away your medicine once the expiration date has passed, which will be 12 weeks from the date you received it from the pharmacy, or 60 days after you first open it, whichever comes first.
What should I tell my healthcare provider before using Twyneo?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Twyneo is right for you.
In particular, make sure that you discuss any of the following.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
- Any other skin conditions, such as cuts or scrapes on the skin, sunburn, or eczema
- Sunlight sensitivity, which means your skin easily gets sunburned or irritated from sun exposure
- Any other medical conditions
Other Medicines and Supplements. Twyneo may interact with other medicines and supplements. Before using Twyneo, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. It is not known if or how Twyneo could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should use Twyneo while you are pregnant or trying to get pregnant.
Breastfeeding. It is not known if Twyneo passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Twyneo while breastfeeding.
How can I get more information about Twyneo?
For more information about Twyneo, you can visit the manufacturer’s website at www.twyneo.com or call them at 866-735-4137.
Interactions
Does Twyneo interact with foods or drinks?
There are no known interactions between Twyneo and foods or drinks.
There are no known interactions between Twyneo and alcohol.
Does Twyneo interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before using Twyneo.
- Any other medicines for acne
- Any medicines or products you apply to your skin
This may not be a complete list of medicines that can interact with Twyneo. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Twyneo?
If you or someone else has used too much Twyneo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Twyneo?
If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only use the next dose. Do not use double or extra doses.
Are you currently using Twyneo (tretinoin/benzoyl peroxide)?
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