The cream form of ruxolitinib is used to treat certain skin conditions such as eczema (atopic dermatitis) and vitiligo. Eczema is an allergic-type condition that causes red, irritated, and itchy skin. Vitiligo is a condition where the immune system attacks skin cells that make the color in your skin. This drug works by weakening the skin's defense (immune) system, which can help relieve symptoms of the skin conditions. Ruxolitinib belongs to a class of drugs known as kinase inhibitors.
How to use Ruxolitinib 1.5 % Topical Cream
Wash your hands with soap and water before using this medication. Apply a thin layer to the affected areas of skin as directed by your doctor, usually twice daily. Rub the medication into the skin gently and completely. Wash your hands after using this product unless your hands are being treated. If your doctor recommends a moisturizer, apply it after this medication.
This product is for use on the skin only. Avoid getting this medication in your eyes or on the inside of your nose or mouth. If you do get the medication in those areas, flush with plenty of water. Do not apply this medication to open wounds or infected areas. Do not cover the treated area with plastic or waterproof bandages unless directed to do so by your doctor.
Use this medication exactly as directed. For treating eczema, your doctor may instruct you to stop using this product once your eczema has cleared and to start using it again if symptoms reappear. Consult your doctor for details. Do not use more than 60 grams of this medication per week or 100 grams every 2 weeks unless directed to do so by your doctor.
Tell your doctor if your condition does not get better (after 8 weeks of treatment for eczema or after 24 weeks of treatment for vitiligo) or if your condition gets worse.
See also Warning section.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
This medication may lower your ability to fight infections. This may make you more likely to get a serious infection or make any infection you have worse. People taking ruxolitinib by mouth have had very serious (possibly fatal) infections (such as fungal infections, tuberculosis, herpes zoster). Tell your doctor right away if you have any signs of infection (such as a sore throat that doesn't go away, cough that doesn't go away, fever, chills, unusual sweating, painful skin rash/blisters).
Cancers (such as skin cancer) and blood clots have been reported in people using ruxolitinib cream. Also, another medication similar to ruxolitinib has, when taken by mouth, caused serious (possibly fatal) side effects, including heart problems, blood clots, and cancer (such as lymphoma). Before using ruxolitinib, tell your doctor or pharmacist if you have a history of heart disease, stroke, cancer, or any risk factors for heart disease (such as high blood pressure, diabetes, previous blood clots, high cholesterol, smoking or history of smoking). Patients who are 50 years of age or older may be at increased risk for heart problems or blood clots. Discuss the risks and benefits of treatment with your doctor. Get medical help right away if you have symptoms such as shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, sudden/severe headaches, trouble speaking, or weakness on one side of the body.
See also Warning section.
Before using ruxolitinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: cancer (such as skin cancer), current/past/returning infections (such as tuberculosis, hepatitis B and C), weakened immune system (for example, following an organ transplant).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this medication and for 4 weeks after stopping treatment is not recommended. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Do not share this medication with others.
Lab and/or medical tests (such as complete blood counts, cholesterol/triglyceride levels, skin exams) may be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.
This medication has been prescribed for your current condition only. Do not use it later for another skin condition unless your doctor tells you to.
If you have eczema, talk with your doctor about other ways to manage your eczema, such as using moisturizers and taking shorter baths/showers.
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.