Uses
What is Camzyos used for?
Camzyos (mavacamten) is commonly used for symptomatic obstructive hypertrophic cardiomyopathy (HCM). HCM is a heart condition where the heart muscle thickens over time, which makes it harder for the heart to pump blood. In obstructive HCM, the thickened muscle blocks blood flow from the heart. This can lead to heart failure and symptoms like shortness of breath, unusual tiredness, dizziness, or fainting.
Learn more about Camzyos for Obstructive Hypertrophic Cardiomyopathy.
Camzyos may also be used for other conditions as determined by your healthcare provider.
How does Camzyos work (mechanism of action)?
The heart muscle contains tiny protein fibers, called myosin and actin, that work together to squeeze and relax the heart. In HCM, there is more myosin activity, which leads to more squeezing of the heart muscle and blocking of blood flow.
Camzyos decreases the amount of myosin to restore balance to squeezing and relaxing of the heart muscle. This allows the heart to pump blood better and improve symptoms.
How is Camzyos supplied (dosage forms)?
Camzyos is available in the following dosage forms that are taken by mouth.
- 2.5 mg oral capsules
- 5 mg oral capsules
- 10 mg oral capsules
- 15 mg oral capsules
How should I store Camzyos?
Camzyos should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
Side Effects
What are the most common side effects of Camzyos?
The most common side effects of Camzyos are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Dizziness
- Fainting
There may be other side effects of Camzyos that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Camzyos?
While less common, the most serious side effects of Camzyos are described below, along with what to do if they happen.
Severe Allergic Reactions. Camzyos may cause allergic reactions, which can be serious. Stop taking Camzyos and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Heart Failure. Camzyos may increase your risk of heart failure, which can be serious. The risk can be higher if you are taking certain medicines, have a serious infection, or have an irregular heartbeat. Tell your healthcare provider right away if you have any of the following symptoms of new or worsening heart failure.
- Shortness of breath or trouble breathing, especially while lying down
- Swelling in your feet, ankles, or legs
- Unusually fast weight gain
- Unusual tiredness
Warnings & Precautions
Who should not use Camzyos?
Allergies to Ingredients. People who are allergic to any of the following should not take Camzyos.
- Camzyos
- Mavacamten
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Camzyos.
Drug Interactions. Camzyos should not be taken while you are using certain other medicines. Before taking Camzyos, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
What should I know about Camzyos before using it?
Do not take Camzyos unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share Camzyos with other people, even if they have the same condition as you. It may harm them.
Keep Camzyos out of the reach of children.
Do not chew, cut, or crush Camzyos.
Camzyos is only available through a special program, from certain pharmacies, and to certain people. It is important that you keep all of your appointments, including labs or other testing, while taking Camzyos. If you have any questions about this program you can go to www.camzyosrems.com or call 833-628-7367.
Camzyos can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how Camzyos affects you.
Your healthcare provider may do certain tests to check your heart function before starting and while you are taking Camzyos. Keep all appointments with your healthcare provider.
If you can become pregnant, you should use effective birth control while taking Camyzos and four months after stopping treatment. Your healthcare provider may do a pregnancy test before starting Camzyos. Certain birth control medicines may be less effective while taking Camzyos. Talk to your healthcare provider about the right birth control for you and back-up methods of birth control.
What should I tell my healthcare provider before using Camzyos?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Camzyos is right for you.
In particular, make sure that you discuss any of the following.
Infection. Infections can increase the risk of heart failure with Camzyos. Tell your healthcare provider if you have an infection or any of the following symptoms.
- Burning or stinging when you pee
- Cough or coughing up blood
- Fever, sweats, chills, or muscle aches
- Shortness of breath
Heart Rhythm Problems. Heart rhythm problems, such as atrial fibrillation or other uncontrolled fast heartbeat (tachycardia), can increase the risk of heart failure with Camzyos. Talk to your healthcare provider if you have a heart rhythm condition or any of the following symptoms.
- Chest pain
- Shortness of breath
- Feeling dizzy, lightheaded, or fainting
- Changes in your heart rate or rhythm, such as a fast, slow, pounding or skipping heartbeat
Heart Failure. Camzyos can cause new or worsening heart failure, which can be serious. Talk to your healthcare provider if you have heart failure and are taking medicines for treating heart failure. Your healthcare provider may do additional tests to check the function of your heart before starting Camzyos.
Pregnancy. Camzyos may cause harm to an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. If you become pregnant or think you may be pregnant, tell your healthcare provider right away. If you become pregnant while taking Camzyos, you can report the pregnancy to the manufacturer by calling 800-721-5072 or at www.bms.com. The manufacturer collects safety information about the use of Camzyos during pregnancy.
Breastfeeding. It is not known if Camyzos passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take Camyzos while breastfeeding.
How can I get more information about Camzyos?
For more information about Camzyos, you can visit the manufacturer’s website at www.camzyos.com or call them at 855-226-9967.
Interactions
Does Camzyos interact with foods or drinks?
Grapefruit or grapefruit juice can increase the levels of Camzyos in the body, which can increase the risk of serious side effects.
It is unknown if drinking alcohol will affect Camzyos. The risk of dizziness may be increased if you drink alcohol while taking Camzyos.
Does Camzyos interact with other medicines (drug interactions)?
Camzyos interacts with many other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before taking Camzyos.
- A birth control pill, patch, or vaginal ring
- A prescription or OTC medicine commonly used for heartburn, such as omeprazole (Prilosec), esomeprazole (Nexium), or cimetidine (Tagamet HB)
- Disopyramide (Norpace), which is a medicine commonly used for an abnormal heart rhythm
- Ranolazine (Aspruzyo Sprinkle), which is a medicine used for chest pain
- A calcium channel blocker, such as diltiazem (Cardizem CD and others) or verapamil (Verelan, Verelan PM), which is a medicine used for high blood pressure or other conditions
- A beta-blocker, such as metoprolol (Lopressor, Toprol XL, and others), atenolol (Tenormin), or propranolol (Inderal LA, Innopran XL), which is a medicine that may be used for certain heart conditions or to reduce blood pressure
Many other medicines may alter the blood levels of Camzyos, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Camzyos. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Camzyos?
If you or someone else has used too much Camzyos, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Camzyos?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses on the same day.