Lurasidone (> 80 mg)/Diltiazem; Verapamil Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Diltiazem and verapamil may slow down how quickly your liver processes lurasidone.

What might happen:

The amount of lurasidone in your blood may increase and cause side effects.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you experience fever, stiff muscles, confusion, changes in heart rate/blood pressure, sweating, muscle pain or weakness, uncontrollable movements of the face/tongue/other body parts, light-headedness or faintness when rising from a sitting position.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Latuda (lurasidone hydrochloride) US prescribing information. Sunovion Pharamceuticals, Inc. February 23, 2017.
  • 2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.